Relationships between lipids levels in blood plasma, follicular fluid and seminal plasma with ovarian response and sperm concentration regardless of age and body mass index

IF 0.8 4区医学 Q4 ANDROLOGY Revista Internacional De Andrologia Pub Date : 2022-07-01 DOI:10.1016/j.androl.2021.02.004

Rocío Núñez Calonge , José Andrés Guijarro , Carolina Andrés , Susana Cortés , Massimiliano Saladino , Pedro Caballero , Roman Kireev

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引用次数: 2

Abstract

Purpose

There is a considerable literature supporting the role of lipids in fertility. However, little is known about their impact on male and female gametes. Our study aimed to investigate the relationships between lipids levels in serum, follicular fluid and seminal plasma with ovarian response and sperm concentration regardless of age and body mass index (BMI).

Methods

51 follicular fluid and serum samples of IVF-ICSI cycles and 52 seminal plasma and serum samples of males in the infertility study were analyzed for cholesterol, triglycerides, and non-esterified fatty acids. The parameters used to assess gonadal response were number of mature oocytes in metaphase II and total motile sperm. Differences between groups were studied by means Principal Component Analysis, Kolmogorov–Smirnov test, Pearson correlation, Student's T, and multivariate linear regression.

Results

Using a multivariate linear regression model to exclude the effect of the age and BMI, we found that the lipid profile in follicular fluid and plasma influence inversely and significantly on ovarian response and the number of matured oocytes recovered. Moreover, we found that seminal lipid levels are predictors of seminal quality independent of plasma lipid values.

Conclusion

Our current analysis demonstrates the association of low ovarian response and low number of motile sperms with abnormal lipids levels.

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血浆、卵泡液和精浆中脂质水平与卵巢反应和精子浓度的关系，与年龄和体重指数无关

目的有相当多的文献支持脂质在生育中的作用。然而，人们对它们对雄性和雌性配子的影响知之甚少。本研究旨在探讨血清、卵泡液和精浆中脂质水平与卵巢反应和精子浓度之间的关系，而不考虑年龄和体重指数(BMI)。方法对51例IVF-ICSI周期的卵泡液和血清样本以及52例不育男性的精浆和血清样本进行胆固醇、甘油三酯和非酯化脂肪酸的分析。用于评估性腺反应的参数是中期成熟卵母细胞的数量和总活动精子。采用主成分分析、Kolmogorov-Smirnov检验、Pearson相关、Student’s T、多元线性回归等方法研究组间差异。结果在排除年龄和BMI影响的多元线性回归模型中，我们发现卵泡液和血浆脂质谱对卵巢反应和成熟卵母细胞恢复数量有显著的负相关影响。此外，我们发现精液脂质水平是独立于血浆脂质值的精液质量的预测因子。结论我们目前的分析表明，低卵巢反应和低运动精子数量与血脂水平异常有关。

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来源期刊

Revista Internacional De Andrologia ANDROLOGY-

CiteScore

1.60

自引率

12.50%

发文量

审稿时长

>12 weeks

期刊介绍： Revista Internacional de Andrología es la revista oficial de la Asociación Española de Andrología, Medicina Sexual y Reproductiva (ASESA), la Sociedade Portuguesa de Ardrologia, la Sociedad Argentina de Andrología (SAA), la Asociación Iberoamericana de Sociedades de Andrología (ANDRO), y la Federación Española de Sociedades de Sexología. La revista publicada trimestralmente es revisada por pares y es líder en el la especialidad y en español y portugués. Recientemente también publica artículos en inglés. El objetivo de la revista es principalmente la promoción del conocimiento y la educación médica continua, con un enfoque especial en el público español y latinoamericano, a través de la publicación de las contribuciones importantes de la investigación en el campo. Todos los miembros de las sociedades antes mencionadas reciben la revista y otros suscriptores individuales e institucionales de España, Portugal y América Latina.