A possible mechanism of erectile dysfunction in coronavirus disease-19: Cavernosal smooth muscle damage: A pilot study

IF 0.8 4区医学 Q4 ANDROLOGY Revista Internacional De Andrologia Pub Date : 2023-10-01 DOI:10.1016/j.androl.2023.100366

Selman Unal, Halil Uzundal, Turker Soydas, Musab A. Kutluhan, Asim Ozayar, Emrah Okulu, Onder Kayigil

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引用次数: 4

Abstract

Introduction

Studies have reported that coronavirus disease 2019 (COVID-19) may cause erectile dysfunction (ED), however, its role in the pathophysiology of ED has not yet been fully elucidated. We aimed to elucidate COVID-19's effects on cavernosal smooth muscle, which has a pretty important role in erection physiology, by corpus cavernosum electromyography (cc-EMG).

Materials and methods

Twenty-nine male patients aged 20–50 years who applied to the urology outpatient clinic due to ED were included in the study. Nine patients that had COVID-19 and were treated as outpatients were classified as group 1, 10 patients who were hospitalized due to COVID-19 were classified as group 2, and 10 patients who did not have COVID-19 were classified as the control group (group 3). Patients underwent diagnostic evaluation including International Index of Erectile Function (IIEF)-5 form, penile color Doppler ultrasonography (CDUS), cc-EMG, and fasting serum levels of reproductive hormones (07–11 am).

Results

According to penile CDUS and hormonal values results, there was no significant difference between the groups. According to cc-EMG results, amplitudes and relaxation capacities of the cavernosal smooth muscle of patients in group 3 were significantly higher than those in the other groups.

Conclusions

COVID-19 can cause ED not only by psychogenic and hormonal factors but also with cavernosal smooth muscle damage.

Clinical Trial Registration Number: NCT04980508.

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冠状病毒疾病中勃起功能障碍的可能机制-19：海绵体平滑肌损伤：一项初步研究。

简介：研究报告2019冠状病毒病（新冠肺炎）可能导致勃起功能障碍（ED），但其在ED病理生理学中的作用尚未完全阐明。我们旨在通过海绵体肌电图（cc-EMG）阐明新冠肺炎对海绵体平滑肌的影响，海绵体在勃起生理中起着非常重要的作用。9名患有新冠肺炎并作为门诊患者接受治疗的患者被分类为第1组，10名因新冠肺炎住院的患者被归类为第2组，10例未患有新冠肺炎的患者被分为对照组（第3组）。患者接受了包括国际勃起功能指数（IIEF）-5型、阴茎彩色多普勒超声（CDUS）、cc-EMG和空腹血清生殖激素水平（上午7点至11点）在内的诊断评估。结果：根据阴茎CDUS和激素值结果，两组之间无显著差异。根据cc-EMG结果，第3组患者的海绵体平滑肌的振幅和松弛能力显著高于其他组。结论：新冠肺炎可引起ED，这不仅是由心理因素和激素因素引起的，而且与海绵体平滑肌损伤有关。临床试验注册号：NCT04980508。

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来源期刊

Revista Internacional De Andrologia ANDROLOGY-

CiteScore

1.60

自引率

12.50%

发文量

审稿时长

>12 weeks

期刊介绍： Revista Internacional de Andrología es la revista oficial de la Asociación Española de Andrología, Medicina Sexual y Reproductiva (ASESA), la Sociedade Portuguesa de Ardrologia, la Sociedad Argentina de Andrología (SAA), la Asociación Iberoamericana de Sociedades de Andrología (ANDRO), y la Federación Española de Sociedades de Sexología. La revista publicada trimestralmente es revisada por pares y es líder en el la especialidad y en español y portugués. Recientemente también publica artículos en inglés. El objetivo de la revista es principalmente la promoción del conocimiento y la educación médica continua, con un enfoque especial en el público español y latinoamericano, a través de la publicación de las contribuciones importantes de la investigación en el campo. Todos los miembros de las sociedades antes mencionadas reciben la revista y otros suscriptores individuales e institucionales de España, Portugal y América Latina.