Thin-slice Two-dimensional T2-weighted Imaging with Deep Learning-based Reconstruction: Improved Lesion Detection in the Brain of Patients with Multiple Sclerosis.

IF 2.5 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Magnetic Resonance in Medical Sciences Pub Date : 2024-04-01 Epub Date: 2023-03-16 DOI:10.2463/mrms.mp.2022-0112
Masatoshi Iwamura, Satoru Ide, Kenya Sato, Akihisa Kakuta, Soichiro Tatsuo, Atsushi Nozaki, Tetsuya Wakayama, Tatsuya Ueno, Rie Haga, Misako Kakizaki, Yoko Yokoyama, Ryoichi Yamauchi, Fumiyasu Tsushima, Koichi Shibutani, Masahiko Tomiyama, Shingo Kakeda
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Abstract

Purpose: Brain MRI with high spatial resolution allows for a more detailed delineation of multiple sclerosis (MS) lesions. The recently developed deep learning-based reconstruction (DLR) technique enables image denoising with sharp edges and reduced artifacts, which improves the image quality of thin-slice 2D MRI. We, therefore, assessed the diagnostic value of 1 mm-slice-thickness 2D T2-weighted imaging (T2WI) with DLR (1 mm T2WI with DLR) compared with conventional MRI for identifying MS lesions.

Methods: Conventional MRI (5 mm T2WI, 2D and 3D fluid-attenuated inversion recovery) and 1 mm T2WI with DLR (imaging time: 7 minutes) were performed in 42 MS patients. For lesion detection, two neuroradiologists counted the MS lesions in two reading sessions (conventional MRI interpretation with 5 mm T2WI and MRI interpretations with 1 mm T2WI with DLR). The numbers of lesions per region category (cerebral hemisphere, basal ganglia, brain stem, cerebellar hemisphere) were then compared between the two reading sessions.

Results: For the detection of MS lesions by 2 neuroradiologists, the total number of detected MS lesions was significantly higher for MRI interpretation with 1 mm T2WI with DLR than for conventional MRI interpretation with 5 mm T2WI (765 lesions vs. 870 lesions at radiologist A, < 0.05). In particular, of the 33 lesions in the brain stem, radiologist A detected 21 (63.6%) additional lesions by 1 mm T2WI with DLR.

Conclusion: Using the DLR technique, whole-brain 1 mm T2WI can be performed in about 7 minutes, which is feasible for routine clinical practice. MRI with 1 mm T2WI with DLR enabled increased MS lesion detection, particularly in the brain stem.

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基于深度学习重建的薄片二维 T2 加权成像:改进多发性硬化症患者脑部病灶检测。
目的:具有高空间分辨率的脑磁共振成像可更详细地划分多发性硬化(MS)病灶。最近开发的基于深度学习的重建(DLR)技术可以对图像进行去噪处理,使边缘清晰并减少伪影,从而提高薄片二维磁共振成像的图像质量。因此,我们评估了薄片厚度为 1 毫米的二维 T2 加权成像(T2WI)与传统 MRI 相比在识别 MS 病灶方面的诊断价值:对42名多发性硬化症患者进行了常规磁共振成像(5毫米T2WI、二维和三维液体减弱反转恢复)和1毫米T2WI与DLR(成像时间:7分钟)。在病灶检测方面,两名神经放射学专家在两次阅片中对多发性硬化症病灶进行了计数(5 毫米 T2WI 的常规 MRI 解读和 1 毫米 T2WI 加 DLR 的 MRI 解读)。然后比较两次阅片中每个区域类别(大脑半球、基底节、脑干、小脑半球)的病变数量:结果:在两位神经放射科医生对多发性硬化病灶的检测中,使用1毫米T2WI和DLR进行磁共振成像解读时,检测到的多发性硬化病灶总数明显高于使用5毫米T2WI进行传统磁共振成像解读时(放射科医生A检测到765个病灶,放射科医生B检测到870个病灶,<0.05)。特别是,在脑干的33个病灶中,放射科医生A通过使用DLR的1毫米T2WI又发现了21个病灶(63.6%):结论:使用 DLR 技术可在约 7 分钟内完成全脑 1 毫米 T2WI,这在常规临床实践中是可行的。使用 DLR 进行 1 毫米 T2WI 的磁共振成像可提高多发性硬化病灶的检出率,尤其是在脑干。
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来源期刊
Magnetic Resonance in Medical Sciences
Magnetic Resonance in Medical Sciences RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
5.80
自引率
20.00%
发文量
71
审稿时长
>12 weeks
期刊介绍: Magnetic Resonance in Medical Sciences (MRMS or Magn Reson Med Sci) is an international journal pursuing the publication of original articles contributing to the progress of magnetic resonance in the field of biomedical sciences including technical developments and clinical applications. MRMS is an official journal of the Japanese Society for Magnetic Resonance in Medicine (JSMRM).
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