Is micronucleus assay a suitable method for biomonitoring children exposed to X-ray? A systematic review with meta-analysis.

IF 2.1 4区医学 Q2 BIOLOGY International Journal of Radiation Biology Pub Date : 2023-01-01 Epub Date: 2023-03-31 DOI:10.1080/09553002.2023.2194405

Ingra Tais Malacarne, Wilton Mitsunari Takeshita, Milena de Barros Viana, Ana Claudia Muniz Renno, Daniel Araki Ribeiro

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Abstract

Purpose: The aim of this study was to evaluate if the micronucleus test using oral epithelial cells is a suitable biomarker for biomonitoring children exposed to X-ray.

Material and methods: A search was performed through the electronic databases PubMed/Medline, Scopus, and Web of Science, all studies published up to February 2022 that examined the relationship between exposure of children to radiographic examinations and micronucleus.

Results: A total of 17 full-text manuscripts were screened for eligibility. Only two studies found a difference in micronucleus labeling. On the other hand, all studies showed that X-ray was able to induce cellular death in oral mucosa cells. Following the parameters of the Effective Practices in Public Health Project (EPHPP), five manuscripts reached moderate and strong scores, and four studies were categorized as weak at final rating. In the meta-analysis, statistically significant difference was detected in micronucleated cells in children before and after radiographic examinations (SMD = 0.96, 95% CI, 0.07-1.84, p = .04), with τ²=1.09; χ²=53.37, and p < .001.

Conclusion: Radiographic examinations in children can cause genotoxic and cytotoxic damage in the oral epithelium with a large effect size.

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微核试验是一种适合于对暴露于X射线的儿童进行生物监测的方法吗？荟萃分析系统综述。

目的：本研究的目的是评估使用口腔上皮细胞的微核试验是否是一种适合于对暴露于X射线的儿童进行生物监测的生物标志物。材料和方法：通过电子数据库PubMed/Medline、Scopus和Web of Science进行搜索，截至2022年2月发表的所有研究都检验了儿童暴露于射线照相检查与微核之间的关系。结果：共筛选出17篇全文稿件。只有两项研究发现微核标记存在差异。另一方面，所有研究都表明，X射线能够诱导口腔粘膜细胞的细胞死亡。根据公共卫生有效实践项目（EPHPP）的参数，有五份手稿达到了中等和较强的分数，四项研究在最终评级中被归类为较弱。在荟萃分析中，儿童放射检查前后的微核细胞存在统计学显著差异（SMD=0.96，95%CI，0.07-1.84，p = .04），其中τ2=1.09；χ2=53.37，p 结论：儿童X线检查可引起口腔上皮细胞的遗传毒性和细胞毒性损伤，影响范围较大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Radiation Biology 医学-核科学技术

CiteScore

5.00

自引率

11.50%

发文量

142

审稿时长

3 months

期刊介绍： The International Journal of Radiation Biology publishes original papers, reviews, current topic articles, technical notes/reports, and meeting reports on the effects of ionizing, UV and visible radiation, accelerated particles, electromagnetic fields, ultrasound, heat and related modalities. The focus is on the biological effects of such radiations: from radiation chemistry to the spectrum of responses of living organisms and underlying mechanisms, including genetic abnormalities, repair phenomena, cell death, dose modifying agents and tissue responses. Application of basic studies to medical uses of radiation extends the coverage to practical problems such as physical and chemical adjuvants which improve the effectiveness of radiation in cancer therapy. Assessment of the hazards of low doses of radiation is also considered.