Fasting Plasma Glucose Increase and Neutrophil-to-Lymphocyte Ratio as Risk Predictors of Clinical Outcome of COVID-19 Pneumonia in Type 2 Diabetes Mellitus.

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-04-01 DOI:10.1055/a-2009-6937

Vasilios Petrakis, Periklis Panagopoulos, Grigorios Trypsianis, Dimitrios Papazoglou, Nikolaos Papanas

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引用次数: 1

Abstract

Aim of the study: To evaluate fasting plasma glucose (FPG) increase and neutrophil-to-lymphocyte ratio (NLR) as risk predictors of severe clinical outcome of COVID-19 pneumonia in type 2 diabetes mellitus (T2DM) hospitalised patients.

Patients and methods: Type 2 diabetes mellitus (T2DM) patients hospitalised between March 2020 and February 2021 were studied retrospectively. The NLR ratio at admission and FPG increase (day 7, day with maximal FPG) were evaluated in association with the clinical progression of SARS-CoV-2 infection.

Results: Three hundred patients (165 men, 135 women) were included in the study. The mean age was 67.17±8.65 years. Severe COVID-19 pneumonia was diagnosed in 170 patients (56.7%). Fifty-four patients (18%) were intubated and 49 (16.3%) died. Greater increase in FPG (79.5 vs. 44.5 mg/dL for day 1-7, p<0.001; and 113.5 vs. 75 mg/dL for day 1-day with maximum glucose value, p<0.001) and higher NLR at admission (10.65 vs. 6.85) were seen in patients with need of high-flow oxygen compared to those without need, and they were associated with a higher probability of intubation and death.

Conclusion: FPG increase and NLR could be significant risk predictors of severe COVID-19 pneumonia in T2DM hospitalised patients.

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空腹血糖升高和中性粒细胞/淋巴细胞比值作为2型糖尿病患者COVID-19肺炎临床结局的危险预测因素

研究目的:评价空腹血糖(FPG)升高和中性粒细胞与淋巴细胞比值(NLR)作为2型糖尿病(T2DM)住院患者COVID-19肺炎严重临床结局的风险预测因子。患者和方法:回顾性研究2020年3月至2021年2月住院的2型糖尿病(T2DM)患者。评估入院时NLR比率和FPG增加(第7天，FPG最大的天数)与SARS-CoV-2感染的临床进展的相关性。结果:300例患者(男性165例，女性135例)纳入研究。平均年龄67.17±8.65岁。重症肺炎170例(56.7%)。54例(18%)患者插管，49例(16.3%)患者死亡。结论:FPG升高和NLR可能是T2DM住院患者重症COVID-19肺炎的重要风险预测因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental and Clinical Endocrinology & Diabetes 医学-内分泌学与代谢

CiteScore

4.10

自引率

5.60%

发文量

审稿时长

3 months

期刊介绍： Publishing outstanding articles from all fields of endocrinology and diabetology, from molecular biology to clinical research, this journal is a brilliant resource. Since being published in English in 1983, the popularity of this journal has grown steadily, reflecting the importance of this publication within its field. Original contributions and short communications appear in each issue along with reviews addressing current topics. In addition, supplementary issues are published each year presenting abstracts or proceedings of national and international scientific meetings. The journal was initially published in German and is still the oldest endocrinological periodical in the German-language market!