Adverse childhood experiences and reoccurrence of illness impact the gut microbiome, which affects suicidal behaviours and the phenome of major depression: towards enterotypic phenotypes.

IF 3.8 4区 医学 Q1 Medicine Acta Neuropsychiatrica Pub Date : 2023-12-01 Epub Date: 2023-04-13 DOI:10.1017/neu.2023.21
Michael Maes, Asara Vasupanrajit, Ketsupar Jirakran, Pavit Klomkliew, Prangwalai Chanchaem, Chavit Tunvirachaisakul, Kitiporn Plaimas, Apichat Suratanee, Sunchai Payungporn
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引用次数: 10

Abstract

The first publication demonstrating that major depressive disorder (MDD) is associated with alterations in the gut microbiota appeared in 2008 (Maes et al., 2008). The purpose of the present study is to delineate a) the microbiome signature of the phenome of depression, including suicidal behaviours (SB) and cognitive deficits; the effects of adverse childhood experiences (ACEs) and recurrence of illness index (ROI) on the microbiome; and the microbiome signature of lowered high-density lipoprotein cholesterol (HDLc). We determined isometric log-ratio abundances or prevalences of gut microbiome phyla, genera, and species by analysing stool samples from 37 healthy Thai controls and 32 MDD patients using 16S rDNA sequencing. Six microbiome taxa accounted for 36% of the variance in the depression phenome, namely Hungatella and Fusicatenibacter (positive associations) and Butyricicoccus, Clostridium, Parabacteroides merdae, and Desulfovibrio piger (inverse association). This profile (labelled enterotype 1) indicates compositional dysbiosis, is strongly predicted by ACE and ROI, and is linked to SB. A second enterotype was developed that predicted a decrease in HDLc and an increase in the atherogenic index of plasma (Bifidobacterium, P. merdae, and Romboutsia were positively associated, while Proteobacteria and Clostridium sensu stricto were negatively associated). Together, enterotypes 1 and 2 explained 40.4% of the variance in the depression phenome, and enterotype 1 in conjunction with HDLc explained 39.9% of the variance in current SB. In conclusion, the microimmuneoxysome is a potential new drug target for the treatment of severe depression and SB and possibly for the prevention of future episodes.

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童年的不良经历和疾病的复发会影响肠道微生物组,从而影响自杀行为和重度抑郁症的表型:走向肠道表型。
2008 年发表的第一篇论文证明,重度抑郁症(MDD)与肠道微生物群的改变有关(Maes 等人,2008 年)。本研究的目的是确定 a) 抑郁症表型的微生物组特征,包括自杀行为(SB)和认知缺陷;不良童年经历(ACE)和疾病复发指数(ROI)对微生物组的影响;以及高密度脂蛋白胆固醇(HDLc)降低的微生物组特征。我们使用 16S rDNA 测序法分析了 37 名泰国健康对照者和 32 名 MDD 患者的粪便样本,从而确定了肠道微生物组各门、属和种的等比对数丰度或流行率。六个微生物群分类群占抑郁表型变异的 36%,即 Hungatella 和 Fusicatenibacter(正相关)以及 Butyricicoccus、Clostridium、Parabacteroides merdae 和 Desulfovibrio piger(反相关)。该特征(标为肠型 1)表明菌群组成失调,受 ACE 和 ROI 的强烈预测,并与 SB 有关。第二种肠型可预测高密度脂蛋白胆固醇(HDLc)的降低和血浆致动脉粥样硬化指数的升高(双歧杆菌、梅尔代梭菌和隆贝氏菌呈正相关,而变形杆菌和严格意义上的梭状芽孢杆菌呈负相关)。肠型 1 和 2 可共同解释抑郁表型中 40.4% 的变异,而肠型 1 与 HDLc 可共同解释当前 SB 中 39.9% 的变异。总之,微免疫氧体是治疗严重抑郁症和 SB 的潜在新药靶点,也可能是预防未来抑郁症发作的新药靶点。
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来源期刊
Acta Neuropsychiatrica
Acta Neuropsychiatrica 医学-精神病学
CiteScore
8.50
自引率
5.30%
发文量
30
审稿时长
6-12 weeks
期刊介绍: Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.
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