Role of six cytokines and bone metabolism biomarkers in gingival crevicular fluid in patients undergoing fixed orthodontic appliance treatment in comparison with aligners: a clinical study.

IF 3 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Angle Orthodontist Pub Date : 2023-02-20 DOI:10.2319/091722-649.1

Muhammad Abdullah Kamran, Abdullah A Alnazeh, Mohammad Almagbol, Salem Almoammar, Ali Hasan A Alhaizaey, Ibrahim Alshahrani

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Abstract

Objectives: The objective of this study was to assess bone biomarkers and cytokines in patients with conventional labial appliances (CLAs) and aligners.

Materials and methods: Participants were recruited to undergo orthodontic treatment with CLAs and aligners according to predefined inclusion and exclusion criteria. Periodontal examination was accomplished at baseline and 4 weeks using the plaque index (PI), gingival index (GI), and bleeding on probing (BoP). Samples of gingival crevicular fluid (GCF) were collected at baseline (T0) before the start of treatment and at the 1-month follow-up (T1) to assess bone metabolic and inflammatory biomarkers. GCF from participants with CLAs and aligners was evaluated with enzyme-linked immunosorbent assay. Comparison between labial conventional orthodontic treatment and aligners were assessed using an unpaired t-test. The difference between T0 and T1 was measured using a paired t-test.

Results: BoP, PI, and GI demonstrated no significant difference between participants treated with aligners and subjects with CLAs at baseline and at 4 weeks (P > .05). Bone markers and other biomarkers (tumor necrosis factor α, interleukin [IL]-α, IL-2, IL-6, and IL-8) showed significant differences (P < .05). Also, a significant difference between CLAs and aligners was noted among all biomarkers (P < .05) except IL-β.

Conclusions: Aligners and CLAs increase the level of inflammatory and bone metabolic biomarkers after 1 month.

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固定矫治器与矫治器治疗患者牙龈缝隙液中六种细胞因子和骨代谢生物标志物的作用对比：一项临床研究。

研究目的本研究的目的是评估传统唇矫治器（CLA）和矫治器患者的骨生物标志物和细胞因子：根据预先确定的纳入和排除标准，招募参与者接受传统唇矫治器和矫治器的正畸治疗。在基线和 4 周时使用牙菌斑指数 (PI)、牙龈指数 (GI) 和探诊出血量 (BoP) 进行牙周检查。在治疗开始前的基线（T0）和随访 1 个月时（T1）收集牙龈缝液（GCF）样本，以评估骨代谢和炎症生物标志物。采用酶联免疫吸附测定法对使用 CLAs 和矫治器的参与者的 GCF 进行评估。唇侧传统正畸治疗与矫治器之间的比较采用非配对 t 检验进行评估。T0和T1之间的差异采用配对t检验：BoP、PI和GI显示，在基线和4周时，接受矫治器治疗的受试者与接受CLA治疗的受试者之间没有明显差异（P > .05）。骨标记物和其他生物标记物（肿瘤坏死因子α、白细胞介素[IL]-α、IL-2、IL-6 和 IL-8）显示出显著差异（P < .05）。此外，除IL-β外，CLA和对准器在所有生物标志物中均存在显著差异（P < .05）：结论：对准器和 CLAs 在一个月后会提高炎症和骨代谢生物标志物的水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Angle Orthodontist 医学-牙科与口腔外科

CiteScore

6.40

自引率

5.90%

发文量

审稿时长

3 months

期刊介绍： The Angle Orthodontist is the official publication of the Edward H. Angle Society of Orthodontists and is published bimonthly in January, March, May, July, September and November by The EH Angle Education and Research Foundation Inc. The Angle Orthodontist is the only major journal in orthodontics with a non-commercial, non-profit publisher -- The E. H. Angle Education and Research Foundation. We value our freedom to operate exclusively in the best interests of our readers and authors. Our website www.angle.org is completely free and open to all visitors.