Neuropeptide Y gene variants and Agreeableness: interaction effect with the birth cohort and the serotonin transporter promoter polymorphism.

IF 3.8 4区 医学 Q1 Medicine Acta Neuropsychiatrica Pub Date : 2024-02-01 Epub Date: 2023-04-18 DOI:10.1017/neu.2023.23
Evelyn Kiive, Margus Kanarik, Toomas Veidebaum, Jaanus Harro
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Abstract

Objective: Neuropeptide Y (NPY) is a powerful regulator of anxious states, including social anxiety, but evidence from human genetic studies is limited. Associations of common gene variants with behaviour have been described as subject to birth cohort effects, especially if the behaviour is socially motivated. This study aimed to examine the association of NPY rs16147 and rs5574 with personality traits in highly representative samples of two birth cohorts of young adults, the samples having been formed during a period of rapid societal transition.

Methods: Both birth cohorts (original n = 1238) of the Estonian Children Personality Behaviour and Health Study (ECPBHS) self-reported personality traits of the five-factor model at 25 years of age.

Results: A significant interaction effect of the NPY rs16147 and rs5574 and birth cohort on Agreeableness was found. The T/T genotype of NPY rs16147 resulted in low Agreeableness in the older cohort (born 1983) and in high Agreeableness in the younger cohort (born 1989). The C/C genotype of NPY rs5574 was associated with higher Agreeableness in the younger but not in the older cohort. In the NPY rs16147 T/T homozygotes, the deviations from average in Agreeableness within the birth cohort were dependent on the serotonin transporter promoter polymorphism.

Conclusions: The association between the NPY gene variants and a personality domain reflecting social desirability is subject to change qualitatively in times of rapid societal changes, serving as an example of the relationship between the plasticity genes and environment. The underlying mechanism may involve the development of the serotonergic system.

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神经肽 Y 基因变异与合意性:与出生队列和血清素转运体启动子多态性的交互效应。
目的:神经肽 Y(Neuropeptide Y,NPY)是焦虑状态(包括社交焦虑)的一个强有力的调节因子,但人类基因研究的证据却很有限。常见的基因变异与行为的关联被描述为受出生队列效应的影响,尤其是当行为是由社会因素引起时。本研究的目的是在两个具有高度代表性的青壮年出生队列样本中研究 NPY rs16147 和 rs5574 与人格特质的关联,这两个出生队列样本是在社会快速转型时期形成的:方法:爱沙尼亚儿童人格行为与健康研究(ECPBHS)的两个出生队列(原始 n = 1238)都对 25 岁时的五因素模型人格特质进行了自我报告:结果发现,NPY rs16147和rs5574与出生队列对 "宜人性 "有明显的交互效应。NPY rs16147的T/T基因型会导致年长组群(1983年出生)中的低度 "合群性 "和年轻组群(1989年出生)中的高度 "合群性"。NPY rs5574的C/C基因型在年轻组群中与较高的可亲和性相关,但在年长组群中则不相关。在NPY rs16147 T/T同卵双生者中,出生队列中的 "可接近性 "与平均值的偏差取决于5-羟色胺转运体启动子多态性:结论:NPY基因变异与反映社会宜人性的人格领域之间的关联在社会快速变化时会发生质的变化,这是可塑性基因与环境之间关系的一个例子。其潜在机制可能涉及血清素能系统的发展。
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来源期刊
Acta Neuropsychiatrica
Acta Neuropsychiatrica 医学-精神病学
CiteScore
8.50
自引率
5.30%
发文量
30
审稿时长
6-12 weeks
期刊介绍: Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.
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