[Role and interest of hepcidin in iron homeostasis].

IF 0.4 4区 医学 Q4 MEDICAL LABORATORY TECHNOLOGY Annales de biologie clinique Pub Date : 2023-05-16 DOI:10.1684/abc.2023.1805
Julien Miozzo, Cécile Meunier, Sophie Park, Patrice Faure, Laetitia Van Noolen
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Abstract

Iron is an essential element to the well functionning of the organism and requires careful maintenance of its homeostasis. This is mainly due to hepcidin, a hormone secreted by the liver that controls the flow of iron within the body. It has a hyposideremic action by reducing the expression of ferroportin, the only protein known to this day, which can export iron into the extracellular environment. This has the effect of decreasing intestinal absorption and increasing intracellular retention, especially in macrophages. Hepcidin is stimulated by elevation of iron and inflammation while activation of erythropoiesis inhibits it. Understanding its regulation allows a better understanding of the pathophysiological mechanisms of overload diseases and iron deficiency. Therefore, hepcidin analysis is interesting for the exploration of iron homeostasis. In combination with other biological parameters of iron status, it is possible to find better instructions for therapeutic managements of iron metabolism diseases. Thus, an assaying method by coupling liquid chromatography and tandem mass spectrometry has been implemented at Grenoble University Hospital and the analytical performances of this assay met the laboratory requirements in terms of reliability of the analysis.

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hepcidin在铁稳态中的作用和兴趣。
铁元素是机体正常运转的必要元素,需要小心地维持体内平衡。这主要是由于肝磷脂,一种由肝脏分泌的激素,控制体内铁的流动。它通过减少铁转运蛋白的表达而具有低铁血症作用,铁转运蛋白是目前已知的唯一一种可以将铁输出到细胞外环境的蛋白质。这具有减少肠道吸收和增加细胞内滞留的作用,特别是在巨噬细胞中。铁和炎症的升高刺激Hepcidin,而红细胞生成的激活则抑制它。了解其调控可以更好地理解超载疾病和缺铁的病理生理机制。因此,hepcidin分析对铁稳态的探索具有重要意义。结合铁状态的其他生物学参数,有可能为铁代谢疾病的治疗管理找到更好的指导。因此,格勒诺布尔大学医院实施了液相色谱-串联质谱联用分析方法,该方法的分析性能在分析可靠性方面满足实验室要求。
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来源期刊
Annales de biologie clinique
Annales de biologie clinique 医学-医学:研究与实验
CiteScore
0.80
自引率
20.00%
发文量
53
审稿时长
6-12 weeks
期刊介绍: Multidisciplinary information with direct relevance to everyday practice Annales de Biologie Clinique, the official journal of the French Society of Clinical Biology (SFBC), supports biologists in areas including continuing education, laboratory accreditation and technique validation. With original articles, abstracts and accounts of everyday practice, the journal provides details of advances in knowledge, techniques and equipment, as well as a forum for discussion open to the entire community.
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