Critical Windows: Exploring the Association Between Perinatal Trauma, Epigenetics, and Chronic Pain.

IF 3.5 3区 医学 Q1 CLINICAL NEUROLOGY Neuroscientist Pub Date : 2024-10-01 Epub Date: 2023-05-22 DOI:10.1177/10738584231176233
Zoe N Kodila, Sandy R Shultz, Glenn R Yamakawa, Richelle Mychasiuk
{"title":"Critical Windows: Exploring the Association Between Perinatal Trauma, Epigenetics, and Chronic Pain.","authors":"Zoe N Kodila, Sandy R Shultz, Glenn R Yamakawa, Richelle Mychasiuk","doi":"10.1177/10738584231176233","DOIUrl":null,"url":null,"abstract":"<p><p>Chronic pain is highly prevalent and burdensome, affecting millions of people worldwide. Although it emerges at any point in life, it often manifests in adolescence. Given that adolescence is a unique developmental period, additional strains associated with persistent and often idiopathic pain lead to significant long-term consequences. While there is no singular cause for the chronification of pain, epigenetic modifications that lead to neural reorganization may underpin central sensitization and subsequent manifestation of pain hypersensitivity. Epigenetic processes are particularly active during the prenatal and early postnatal years. We demonstrate how exposure to various traumas, such as intimate partner violence while in utero or adverse childhood experiences, can significantly influence epigenetic regulation within the brain and in turn modify pain-related processes. We provide compelling evidence that the burden of chronic pain is likely initiated early in life, often being transmitted from mother to offspring. We also highlight two promising prophylactic strategies, oxytocin administration and probiotic use, that have the potential to attenuate the epigenetic consequences of early adversity. Overall, we advance understanding of the causal relationship between trauma and adolescent chronic pain by highlighting epigenetic mechanisms that underlie this transmission of risk, ultimately informing how to prevent this rising epidemic.</p>","PeriodicalId":49753,"journal":{"name":"Neuroscientist","volume":null,"pages":null},"PeriodicalIF":3.5000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439237/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroscientist","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/10738584231176233","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/5/22 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Chronic pain is highly prevalent and burdensome, affecting millions of people worldwide. Although it emerges at any point in life, it often manifests in adolescence. Given that adolescence is a unique developmental period, additional strains associated with persistent and often idiopathic pain lead to significant long-term consequences. While there is no singular cause for the chronification of pain, epigenetic modifications that lead to neural reorganization may underpin central sensitization and subsequent manifestation of pain hypersensitivity. Epigenetic processes are particularly active during the prenatal and early postnatal years. We demonstrate how exposure to various traumas, such as intimate partner violence while in utero or adverse childhood experiences, can significantly influence epigenetic regulation within the brain and in turn modify pain-related processes. We provide compelling evidence that the burden of chronic pain is likely initiated early in life, often being transmitted from mother to offspring. We also highlight two promising prophylactic strategies, oxytocin administration and probiotic use, that have the potential to attenuate the epigenetic consequences of early adversity. Overall, we advance understanding of the causal relationship between trauma and adolescent chronic pain by highlighting epigenetic mechanisms that underlie this transmission of risk, ultimately informing how to prevent this rising epidemic.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
关键之窗:探索围产期创伤、表观遗传学和慢性疼痛之间的关联。
慢性疼痛发病率高、负担重,影响着全球数百万人。虽然慢性疼痛出现在人生的任何阶段,但它通常在青春期表现出来。鉴于青春期是一个特殊的发育时期,与持续性疼痛(通常是特发性疼痛)相关的额外压力会导致严重的长期后果。虽然疼痛的慢性化没有单一的原因,但导致神经重组的表观遗传学改变可能是中枢敏感化和随后痛觉过敏症表现的基础。表观遗传过程在产前和产后早期尤为活跃。我们展示了暴露于各种创伤(如子宫内的亲密伴侣暴力或不良童年经历)是如何显著影响大脑内的表观遗传调控并进而改变疼痛相关过程的。我们提供了令人信服的证据,证明慢性疼痛的负担很可能在生命早期就已开始,而且往往会从母亲传给后代。我们还强调了两种很有前景的预防策略,即催产素的应用和益生菌的使用,它们有可能减轻早期逆境的表观遗传后果。总之,我们通过强调这种风险传播的表观遗传学机制,加深了人们对创伤与青少年慢性疼痛之间因果关系的理解,最终为如何预防这种日益流行的疾病提供了参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Neuroscientist
Neuroscientist 医学-临床神经学
CiteScore
11.50
自引率
0.00%
发文量
68
期刊介绍: Edited by Stephen G. Waxman, The Neuroscientist (NRO) reviews and evaluates the noteworthy advances and key trends in molecular, cellular, developmental, behavioral systems, and cognitive neuroscience in a unique disease-relevant format. Aimed at basic neuroscientists, neurologists, neurosurgeons, and psychiatrists in research, academic, and clinical settings, The Neuroscientist reviews and updates the most important new and emerging basic and clinical neuroscience research.
期刊最新文献
Empathic pain: Underlying neural mechanism. Hidden in the white matter: Current views on interstitial white matter neurons. The Endoplasmic Reticulum and Its Contacts: Emerging Roles in Axon Development, Neurotransmission, and Degeneration. BDNF: New Views of an Old Player in Traumatic Brain Injury. Critical Windows: Exploring the Association Between Perinatal Trauma, Epigenetics, and Chronic Pain.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1