Cingulate cortical thickness in cocaine use disorder: mediation effect between early life stress and cocaine consumption.

IF 3.8 4区 医学 Q1 Medicine Acta Neuropsychiatrica Pub Date : 2024-04-01 Epub Date: 2022-11-23 DOI:10.1017/neu.2022.33
Augusto Martins Lucas Bittencourt, Bárbara Luiza Belmonte da Silveira, Lucca Pizzato Tondo, Leonardo Melo Rothmann, Alexandre Rosa Franco, Pedro Eugenio Mazzucchi Santana Ferreira, Thiago Wendt Viola, Rodrigo Grassi-Oliveira
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Abstract

Objective: The cingulate gyrus is implicated in the neurobiology of addiction, such as chronic cocaine consumption. Early life stress (ELS) is an important moderator of cocaine use disorder (CUD). Therefore, we investigated the effect of CUD on cingulate cortical thickness and tested whether a history of ELS could influence the effects of CUD.

Methods: Participants aged 18-50 years (78 with CUD due to crack cocaine consumption and 53 healthy controls) underwent magnetic resonance imaging and the cingulate thickness (rostral anterior, caudal anterior, posterior, and isthmus regions) was analysed. The clinical assessment comprised the Childhood Trauma Questionnaire (CTQ) and the Addiction Severity Index. Group comparisons adjusting by sex, age, and education were performed. Mediation models were generated where lifetime cocaine use, CTQ score, and cortical thickness corresponded to the independent variable, intermediary variable, and outcome, respectively.

Results: Group comparisons revealed significant differences in six out of eight cingulate cortices, showing lower thickness in the CUD group. Furthermore, years of regular cocaine use was the variable most associated with cingulate thickness. Negative correlations were found between CTQ scores and the isthmus cingulate (right hemisphere), as well as with the rostral anterior cingulate (left hemisphere). In the mediation analysis, we observed a significant negative direct effect of lifetime cocaine use on the isthmus cingulate and an indirect effect of cocaine use mediated by CTQ score.

Conclusion: Our findings suggest that a history of ELS could aggravate the negative effects of chronic cocaine use on the cingulate gyrus, particularly in the right isthmus cingulate cortex.

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可卡因使用障碍中的扣带回皮质厚度:早期生活压力与可卡因消费之间的中介效应。
目的:扣带回与成瘾(如长期吸食可卡因)的神经生物学有关。早期生活压力(ELS)是可卡因使用障碍(CUD)的一个重要调节因素。因此,我们研究了可卡因使用障碍对扣带回皮质厚度的影响,并测试了早期生活压力史是否会影响可卡因使用障碍的影响:年龄在 18-50 岁之间的参与者(78 名因吸食快克可卡因而患有 CUD 的患者和 53 名健康对照者)接受了磁共振成像检查,并对扣带皮层厚度(喙前区、尾前区、后区和峡区)进行了分析。临床评估包括儿童创伤问卷(CTQ)和成瘾严重程度指数。根据性别、年龄和教育程度进行了分组比较。在生成的中介模型中,可卡因使用年限、CTQ得分和皮质厚度分别对应于自变量、中介变量和结果:分组比较显示,在八个扣带回皮质中,有六个存在显著差异,CUD 组的皮质厚度较低。此外,经常使用可卡因的年数是与扣带皮层厚度最相关的变量。CTQ 分数与扣带回峡(右半球)以及喙前扣带回(左半球)之间呈负相关。在中介分析中,我们观察到终生吸食可卡因对扣带回峡部有显著的负向直接影响,而可卡因的使用则通过CTQ评分产生间接影响:我们的研究结果表明,长期吸食可卡因会加重扣带回,尤其是右侧扣带峡部皮层的负面影响。
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来源期刊
Acta Neuropsychiatrica
Acta Neuropsychiatrica 医学-精神病学
CiteScore
8.50
自引率
5.30%
发文量
30
审稿时长
6-12 weeks
期刊介绍: Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.
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