The impact of COVID-19 on acute myeloid leukemia patients undergoing allogeneic stem cell transplantation: a concise review.

IF 2.3 Q2 HEMATOLOGY Blood Research Pub Date : 2023-03-31 DOI:10.5045/br.2023.2022144
Reham Osama Mansour, Shaimaa El-Ashwah, May Denewer
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Abstract

This study aimed to delineate the possible impact of COVID-19 on acute myeloid leukemia (AML) patients in terms of diagnosis, chemotherapy, bone marrow transplant, and vaccination response. Allogeneic stem cell transplantation is markedly affected by the COVID-19 pandemic, as both donors and recipients must be healthy for transplantation to be feasible and successful. Delays in the identification of well-matched donors have been predicted, and represent a special challenge. Therefore, future donors should be tested for COVID-19. The outcome of delayed transplantation is vague and masked by variations in stem cell source along with disease subtype. However, if transplant delay results in recurrence of minimal residual disease, a negative impact on survival is anticipated.

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COVID-19对异基因干细胞移植急性髓系白血病患者影响的简要综述
本研究旨在从诊断、化疗、骨髓移植和疫苗接种反应等方面描述COVID-19对急性髓性白血病(AML)患者可能产生的影响。同种异体干细胞移植受到COVID-19大流行的显著影响,因为供体和受体都必须健康,才能使移植可行和成功。已经预测到在确定匹配良好的捐助者方面会出现延误,这是一项特殊的挑战。因此,未来的捐助者应接受COVID-19检测。延迟移植的结果是模糊的,并被干细胞来源和疾病亚型的变化所掩盖。然而,如果移植延迟导致最小残留疾病的复发,预计会对生存产生负面影响。
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来源期刊
Blood Research
Blood Research HEMATOLOGY-
CiteScore
3.70
自引率
0.00%
发文量
64
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