Christina A Wicker, Taylor Petery, Poornima Dubey, Trisha M Wise-Draper, Vinita Takiar
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引用次数: 0
Abstract
The application of radiotherapy to the treatment of cancer has existed for over 100 years. Although its use has cured many, much work remains to be done to minimize side effects, and in-field tumor recurrences. Resistance of the tumor to a radiation-mediated death remains a complex issue that results in local recurrence and significantly decreases patient survival. Here, we review mechanisms of radioresistance and selective treatment combinations that improve the efficacy of the radiation that is delivered. Further investigation into the underlying mechanisms of radiation resistance is warranted to develop not just novel treatments, but treatments with improved safety profiles relative to current radiosensitizers. This review is written in memory and honor of Dr. Peter Stambrook, an avid scientist and thought leader in the field of DNA damage and carcinogenesis, and a mentor and advocate for countless students and faculty.
应用放射疗法治疗癌症已有 100 多年的历史。尽管放疗治愈了许多患者,但要最大限度地减少副作用和现场肿瘤复发,仍有许多工作要做。肿瘤对辐射介导的死亡的抵抗仍然是一个复杂的问题,它会导致局部复发,并大大降低患者的生存率。在此,我们回顾了放射抗性的机制和可提高放射疗效的选择性治疗组合。我们有必要进一步研究放射抗性的内在机制,以便开发出不仅是新型治疗方法,而且相对于目前的放射增敏剂具有更好安全性的治疗方法。彼得-斯坦布鲁克博士是 DNA 损伤和致癌领域的狂热科学家和思想领袖,也是无数师生的导师和倡导者。
期刊介绍:
The journal is dedicated to extensive reviews, minireviews, and special theme issues on topics of current interest in basic and patient-oriented cancer research. The study of systems biology of cancer with its potential for molecular level diagnostics and treatment implies competence across the sciences and an increasing necessity for cancer researchers to understand both the technology and medicine. The journal allows readers to adapt a better understanding of various fields of molecular oncology. We welcome articles on basic biological mechanisms relevant to cancer such as DNA repair, cell cycle, apoptosis, angiogenesis, tumor immunology, etc.