The Phytochemistry of Ganoderma Species and their Medicinal Potentials.

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL ACS Applied Energy Materials Pub Date : 2023-01-01 DOI:10.1142/S0192415X23500404

Renald Blundell, Emma Camilleri, Bikash Baral, Tomasz M Karpiński, Edlira Neza, Omar M Atrooz

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Abstract

The Ganoderma genus is known for its diverse use as a functional food and therapeutic agent. This fungus has over 428 species, with Ganoderma lucidum being the most studied. The Ganoderma species produce several secondary metabolites and bioactive compounds like polysaccharides, phenols, and triterpenes, which are largely responsible for their therapeutic properties. Throughout this review, several extracts obtained from Ganoderma species have been studied to delve into their therapeutic characteristics and mechanisms. Such properties like immunomodulation, antiaging, antimicrobial, and anticancer activities have been demonstrated by several Ganoderma species and are supported by a large body of evidence. Although its phytochemicals play a vital role in its therapeutic properties, identifying the therapeutic potentials of fungal-secreted metabolites for human health-promoting benefits is a challenging task. Identification of novel compounds with distinct chemical scaffolds and their mechanism of action could help suppress the spread of rising pathogens. Thus, this review provides an updated and comprehensive overview of the bioactive components in different Ganoderma species and the underlying physiological mechanisms.

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灵芝的植物化学成分及其药用价值。

灵芝属以其作为功能性食品和治疗剂的多种用途而闻名。这种真菌有超过428种，其中灵芝是研究最多的。灵芝产生几种次生代谢物和生物活性化合物，如多糖、酚类和三萜，这在很大程度上是其治疗特性的原因。在这篇综述中，研究了几种从灵芝物种中获得的提取物，以深入研究它们的治疗特性和机制。这些特性，如免疫调节、抗衰老、抗菌和抗癌活性，已经被一些灵芝物种证明，并得到大量证据的支持。虽然其植物化学物质在其治疗特性中起着至关重要的作用，但确定真菌分泌的代谢物对人类健康促进的治疗潜力是一项具有挑战性的任务。鉴定具有不同化学支架的新化合物及其作用机制有助于抑制上升病原体的传播。因此，本文综述了不同种类灵芝的生物活性成分及其生理机制的最新和全面综述。

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.