Effect of dialyzer geometry on coagulation activation in the extracorporeal circuit in maintenance hemodialysis patients: Prospective randomized trial.

IF 1.5 4区医学 Q3 HEMATOLOGY Therapeutic Apheresis and Dialysis Pub Date : 2023-08-01 DOI:10.1111/1744-9987.13975

Hesham ElSayed, Khalid Samir Sayed, Mohamed Sary Gharib

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引用次数: 1

Abstract

Background and objectives: The coagulation cascade is activated during hemodialysis (HD) due to interaction of blood with the dialysis circuit. There is a paucity of data on the effect of the physical structure of the dialyzers on coagulation activation during HD. We conducted this study to compare the effect of Helixone FX80 versus Platinum H4 dialyzers on coagulation activation during HD.

Methods: Twenty patients on maintenance HD were enrolled in this randomized prospective crossover study. Each patient was dialyzed using Helixone FX80 and Platinum H4 dialyzers. Serum thrombin-antithrombin complex (TAT) was measured before (T0h) and at the end (T4H) of HD.

Results: The absolute changes of serum TAT were comparable with the two dialyzers (median [IQR]: 1.15 [0.65, 1.75] for Helixone FX80 vs. 1.15 [0.67, 2.05] for Platinum H4, p = 0.371).

Conclusion: Helixone FX80 and Platinum H4 dialyzers have similar effects on coagulation activation during HD.

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透析器几何形状对维持性血液透析患者体外循环凝血激活的影响:前瞻性随机试验。

背景和目的:在血液透析(HD)期间，由于血液与透析回路的相互作用，凝血级联被激活。关于透析器的物理结构对HD期间凝血活化的影响的数据缺乏。我们进行了这项研究，以比较Helixone FX80和铂H4透析剂对HD患者凝血激活的影响。方法:20例维持性HD患者被纳入这项随机前瞻性交叉研究。每位患者均采用Helixone FX80和Platinum H4透析器进行透析。测定血清凝血酶-抗凝血酶复合物(TAT)在HD前(T0h)和晚期(T4H)。结果:两种透析剂血清TAT的绝对变化具有可比性(Helixone FX80的中位[IQR]: 1.15 [0.65, 1.75]， Platinum H4的中位[IQR]: 1.15 [0.67, 2.05]， p = 0.371)。结论:Helixone FX80与铂H4透析剂对HD患者凝血激活作用相似。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapeutic Apheresis and Dialysis 医学-泌尿学与肾脏学

CiteScore

3.00

自引率

10.50%

发文量

166

审稿时长

6-12 weeks

期刊介绍： Therapeutic Apheresis and Dialysis is the official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis and the Japanese Society for Dialysis Therapy. The Journal publishes original articles, editorial comments, review articles, case reports, meeting abstracts and Communications information on apheresis and dialysis technologies and treatments.