Omentin-1 and diabetes: more evidence but far from enough.

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM Archives of Physiology and Biochemistry Pub Date : 2024-12-01 Epub Date: 2023-07-03 DOI:10.1080/13813455.2023.2230380

Jing Xu, Min Li, Xinli Jiang, Yuling Wang, Huijie Ma, Yaru Zhou, Meimei Tian, Yan Liu

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Abstract

Aims and background: Omentin-1 (oment-1) is a type of adipokines that is mainly expressed in visceral fat tissue. Based on accumulating evidence, oment-1 is closely related to diabetes and its complications. However, so far data about oment-1 and diabetes is fragmented. In this review, we focus on the role of oment-1 on diabetes, including its possible signalling pathways, the correlation of circulating omens-1 levels with diabetes and its complications.

Methods: The web of PubMed was searched for articles of relevant studies published until February, 2023.

Results and conclusions: Oment-1 might exert its effects by inhibiting the NF-κB pathway and activating the Akt and AMPK-dependent pathways. The level of circulating oment-1 is negatively correlated with the occurrence of type 2 diabetes and some complications, including diabetic vascular disease, cardiomyopathy, and retinopathy, which can be affected by anti-diabetic therapies. Oment-1 could be a promising marker for screening and targeted therapy for diabetes and its complications; however, more studies are still needed.

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Omentin-1和糖尿病:更多证据，但还远远不够。

目的与背景:Omentin-1 (Omentin-1)是一种主要表达于内脏脂肪组织的脂肪因子。越来越多的证据表明，comment -1与糖尿病及其并发症密切相关。然而，到目前为止，关于评论-1和糖尿病的数据是碎片化的。在这篇综述中，我们将重点介绍omen -1在糖尿病中的作用，包括其可能的信号通路，循环中omen -1水平与糖尿病及其并发症的相关性。方法:检索PubMed网站至2023年2月发表的相关研究文章。结果和结论:omt -1可能通过抑制NF-κB通路，激活Akt和ampk依赖性通路发挥作用。2型糖尿病及糖尿病血管病、心肌病、视网膜病变等并发症的发生与循环中网膜-1的水平呈负相关，这些并发症可受抗糖尿病治疗的影响。comment -1可能成为糖尿病及其并发症筛查和靶向治疗的有前景的标志物;然而，还需要更多的研究。

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来源期刊

Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY

CiteScore

6.90

自引率

3.30%

发文量

期刊介绍： Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.