CTRR-ncRNA: A Knowledgebase for Cancer Therapy Resistance and Recurrence Associated Non-coding RNAs

IF 11.5 2区生物学 Q1 GENETICS & HEREDITY Genomics, Proteomics & Bioinformatics Pub Date : 2023-04-01 DOI:10.1016/j.gpb.2022.10.003

Tong Tang , Xingyun Liu , Rongrong Wu , Li Shen , Shumin Ren , Bairong Shen

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Abstract

Cancer therapy resistance and recurrence (CTRR) are the dominant causes of death in cancer patients. Recent studies have indicated that non-coding RNAs (ncRNAs) can not only reverse the resistance to cancer therapy but also are crucial biomarkers for the evaluation and prediction of CTRR. Herein, we developed CTRR-ncRNA, a knowledgebase of CTRR-associated ncRNAs, aiming to provide an accurate and comprehensive resource for research involving the association between CTRR and ncRNAs. Compared to most of the existing cancer databases, CTRR-ncRNA is focused on the clinical characterization of cancers, including cancer subtypes, as well as survival outcomes and responses to personalized therapy of cancer patients. Information pertaining to biomarker ncRNAs has also been documented for the development of personalized CTRR prediction. A user-friendly interface and several functional modules have been incorporated into the database. Based on the preliminary analysis of genotype–phenotype relationships, universal ncRNAs have been found to be potential biomarkers for CTRR. The CTRR-ncRNA is a translation-oriented knowledgebase and it provides a valuable resource for mechanistic investigations and explainable artificial intelligence-based modeling. CTRR-ncRNA is freely available to the public at http://ctrr.bioinf.org.cn/.

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CTRR-ncRNA：癌症治疗耐药性和复发相关非编码RNA的知识库。

癌症治疗耐药性和复发（CTRR）是癌症患者死亡的主要原因。最近的研究表明，非编码RNA（ncRNA）不仅可以逆转对癌症治疗的耐药性，而且是评估和预测CTRR的关键生物标志物。在此，我们开发了CTRR-ncRNA，这是一个CTRR相关ncRNA的知识库，旨在为CTRR与ncRNA之间的关联研究提供准确而全面的资源。与大多数现有的癌症数据库相比，CTRR-ncRNA专注于癌症的临床特征，包括癌症亚型，以及癌症患者的生存结果和个性化治疗反应。与生物标志物ncRNA相关的信息也已被记录用于开发个性化CTRR预测。一个用户友好的界面和几个功能模块已被纳入数据库。基于基因型-表型关系的初步分析，普遍的ncRNA已被发现是CTRR的潜在生物标志物。CTRR-ncRNA是一个面向翻译的知识库，它为机制研究和可解释的基于人工智能的建模提供了宝贵的资源。CTRR-ncRNA可在http://ctrr.bioinf.org.cn/.

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Genomics, Proteomics & Bioinformatics Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

14.30

自引率

4.20%

发文量

844

审稿时长

61 days

期刊介绍： Genomics, Proteomics and Bioinformatics (GPB) is the official journal of the Beijing Institute of Genomics, Chinese Academy of Sciences / China National Center for Bioinformation and Genetics Society of China. It aims to disseminate new developments in the field of omics and bioinformatics, publish high-quality discoveries quickly, and promote open access and online publication. GPB welcomes submissions in all areas of life science, biology, and biomedicine, with a focus on large data acquisition, analysis, and curation. Manuscripts covering omics and related bioinformatics topics are particularly encouraged. GPB is indexed/abstracted by PubMed/MEDLINE, PubMed Central, Scopus, BIOSIS Previews, Chemical Abstracts, CSCD, among others.