Protective Effects of Chrysin on Hippocampal Damage Induced by Chlorpyrifos in Adult Rats.

Q3 Pharmacology, Toxicology and Pharmaceutics Current drug discovery technologies Pub Date : 2023-01-01 DOI:10.2174/1570163820666230302093111

Behzad Mesbahzadeh, Abolfazl Hatami-Moghaddam, Kobra Naseri, Amir Masoud Jafari-Nozad, Saeed Samarghandian, Tahereh Farkhondeh

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Abstract

Objective: This study aimed to evaluate the possible effects of chlorpyrifos on the rat hippocampus and evaluate whether these effects can be decreased with chrysin co-administration in an animal model.

Methods: Male Wistar rats were randomly divided into 5 groups; Control (C), Chlorpyrifos (CPF), Chlorpyrifos + Chrysin (12.5 mg/kg) (CPF + CH1), Chlorpyrifos + Chrysin (25 mg/kg) (CPF + CH2), Chlorpyrifos + Chrysin (50 mg/kg) (CPF + CH3). After 45 days, hippocampus tissues were evaluated by biochemical and histopathological tests.

Results: Biochemical findings indicated that CPF and CPF plus CH administration could not significantly change SOD activity, and MAD, GSH, and NO levels in the hippocampus tissue of animals versus controls. Histopathological findings of the toxic effects of CPF on hippocampus tissue as evidenced by inflammatory cell infiltration, degeneration/necrosis, and mild hyperemia. CH could ameliorate these histopathological changes in a dose-dependent manner.

Conclusion: In conclusion, CH was effective against histopathological damage induced by CPF in the hippocampus through modulating inflammation and apoptosis.

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黄菊花素对毒死蜱致成年大鼠海马损伤的保护作用。

目的:探讨毒死蜱对大鼠海马可能产生的影响，并在动物模型上评价毒死蜱与黄菊花素合用是否能降低其对海马的影响。方法:雄性Wistar大鼠随机分为5组;对照品(C)、毒死蜱(CPF)、毒死蜱+毒死蜱(12.5 mg/kg) (CPF + CH1)、毒死蜱+毒死蜱(25 mg/kg) (CPF + CH2)、毒死蜱+毒死蜱(50 mg/kg) (CPF + CH3)。45 d后，通过生化和组织病理学检查评估海马组织。结果:生物化学结果表明，CPF和CPF + CH给药对动物海马组织SOD活性、MAD、GSH和NO水平均无显著影响。CPF对海马组织的毒性作用的组织病理学结果为炎症细胞浸润、变性/坏死和轻度充血。CH可以以剂量依赖的方式改善这些组织病理学改变。结论:综上所述，CH通过调节炎症和细胞凋亡对CPF诱导的海马组织病理损伤有一定的抑制作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current drug discovery technologies Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

CiteScore

3.70

自引率

0.00%

发文量

期刊介绍： Due to the plethora of new approaches being used in modern drug discovery by the pharmaceutical industry, Current Drug Discovery Technologies has been established to provide comprehensive overviews of all the major modern techniques and technologies used in drug design and discovery. The journal is the forum for publishing both original research papers and reviews describing novel approaches and cutting edge technologies used in all stages of drug discovery. The journal addresses the multidimensional challenges of drug discovery science including integration issues of the drug discovery process.