Comparison the effect of valerian and gabapentin on RLS and sleep quality in hemodialysis patients: A randomized clinical trial.

IF 1.5 4区医学 Q3 HEMATOLOGY Therapeutic Apheresis and Dialysis Pub Date : 2023-08-01 DOI:10.1111/1744-9987.13987

Iman Hajizadeh, Mahdieh Jamshidi, Majid Kazemi, Hossein Kargar, Tabandeh Sadeghi

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Abstract

Introduction: This study aimed to compare the effect of valerian and gabapentin on restless legs syndrome (RLS) and sleep quality in HD patients.

Methods: In this cross over clinical trial study, 40 HD patients allocated into a valerian and gabapentin group. In the first phase of the study, Group A received valerian and Group B received gabapentin 1 h before bedtime for 1 month. In the second phase, the two groups' treatment regimen was swapped. After a 1-month washout period, the same process was repeated on the crossover groups.

Results: After the first phase, the mean score of RLS was lower in the gabapentin group. But there was no statistically significant difference between the two groups in terms of sleep quality score before and after the first and second interventions.

Conclusion: Gabapentin is more effective than valerian in improving RLS, but both are equally effective in improving sleep quality.

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缬草和加巴喷丁对血液透析患者睡眠质量和睡眠行为的影响:一项随机临床试验。

本研究旨在比较缬草和加巴喷丁对HD患者不宁腿综合征(RLS)和睡眠质量的影响。方法:将40例HD患者分为缬草加巴喷丁组。在第一阶段的研究中，A组在睡前1小时服用缬草，B组在睡前1小时服用加巴喷丁，持续1个月。在第二阶段，两组的治疗方案互换。在1个月的洗脱期后，在交叉组重复同样的过程。结果:第一阶段结束后，加巴喷丁组RLS平均评分较低。但在第一次和第二次干预前后，两组之间的睡眠质量评分没有统计学上的显著差异。结论:加巴喷丁改善RLS的效果优于缬草，但两者改善睡眠质量的效果相同。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapeutic Apheresis and Dialysis 医学-泌尿学与肾脏学

CiteScore

3.00

自引率

10.50%

发文量

166

审稿时长

6-12 weeks

期刊介绍： Therapeutic Apheresis and Dialysis is the official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis and the Japanese Society for Dialysis Therapy. The Journal publishes original articles, editorial comments, review articles, case reports, meeting abstracts and Communications information on apheresis and dialysis technologies and treatments.