Primacy and recency effects in verbal memory are differentially associated with post-mortem frontal cortex p-tau 217 and 202 levels in a mixed sample of community-dwelling older adults.

IF 1.8 4区 心理学 Q3 CLINICAL NEUROLOGY Journal of clinical and experimental neuropsychology Pub Date : 2023-10-01 Epub Date: 2023-07-13 DOI:10.1080/13803395.2023.2232583
Kristina M Gicas, William G Honer, Vladislav A Petyuk, Robert S Wilson, Patricia A Boyle, Sue E Leurgans, Julie A Schneider, Philip L De Jager, David A Bennett
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Abstract

Introduction: Serial position effects in verbal memory are associated with in vivo fluid biomarkers and neuropathological outcomes in Alzheimer's disease (AD). To extend the biomarker literature, associations between serial position scores and postmortem levels of brain phosphorylated tau (p-tau) were examined, in the context of Braak stage of neurofibrillary tangle progression.

Method: Participants were 1091 community-dwelling adults (Mage = 80.2, 68.9% female) from the Rush University Religious Orders Study and Memory and Aging Project who were non-demented at enrollment and followed for a mean of 9.2 years until death. The CERAD Word List Memory test administered at baseline and within 1 year of death was used to calculate serial position (primacy, recency) and total recall scores. Proteomic analyses quantified p-tau 217 and 202 from dorsolateral prefrontal cortex samples. Linear regressions assessed associations between cognitive scores and p-tau with Braak stage as a moderator.

Results: Cognitive status proximal to death indicated 34.7% were unimpaired, 26.2% met criteria for MCI, and 39.0% for dementia. Better baseline primacy recall, but not recency recall, was associated with lower p-tau 217 levels across Braak stages. Delayed recall showed a similar pattern as primacy. There was no main effect of immediate recall, but an interaction with Braak stages indicated a negative association with p-tau 217 level only in Braak V-VI. Within 1 year of death, there were no main effects for cognitive scores; however, recency, immediate and delayed recall scores interacted with Braak stage showing better recall was associated with lower p-tau 217 only in Braak V-VI. No associations were observed with p-tau 202.

Conclusions: Primacy recall measured in non-demented adults may be sensitive to emergent tau phosphorylation that occurs in the earliest stages of AD. Serial position scores may complement the routinely used delayed recall score and p-tau biomarkers to detect preclinical AD.

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在社区居住的老年人混合样本中,言语记忆中的首要效应和追忆效应与死后额叶皮层 p-tau 217 和 202 水平有不同的关联。
简介言语记忆中的序列位置效应与阿尔茨海默病(AD)的体内体液生物标志物和神经病理学结果有关。为了扩展生物标志物文献,我们结合神经纤维缠结发展的布拉克阶段,研究了序列位置得分与脑磷酸化 tau(p-tau)的尸检水平之间的关联:研究对象是拉什大学宗教团体研究和记忆与衰老项目中的1091名社区成年人(年龄=80.2,68.9%为女性),他们在入组时均无痴呆症,平均随访9.2年直至死亡。在基线和死亡后一年内进行的 CERAD 单词表记忆测试被用来计算序列位置(主要性、再现性)和总回忆分数。蛋白质组分析量化了背外侧前额叶皮层样本中的 p-tau 217 和 202。线性回归评估了认知评分与p-tau之间的关联,并以Braak阶段作为调节因子:结果:死亡前的认知状况显示,34.7%的人无认知障碍,26.2%的人符合 MCI 标准,39.0%的人符合痴呆标准。在不同的布拉克阶段,较好的基线原始回忆(而非回顾回忆)与较低的 p-tau 217 水平相关。延迟回忆的模式与基线回忆类似。即时回忆没有主效应,但与 Braak 阶段的交互作用表明,只有在 Braak V-VI 阶段与 p-tau 217 水平呈负相关。在死亡后 1 年内,认知评分没有主效应;但是,回忆、即时回忆和延迟回忆评分与 Braak 阶段的交互作用表明,只有在 Braak V-VI 阶段,较好的回忆与较低的 p-tau 217 相关。结论:结论:在非痴呆成人中测量的原始回忆可能对发生在AD早期阶段的新出现的tau磷酸化很敏感。序列位置评分可以补充常规使用的延迟回忆评分和p-tau生物标志物,以检测临床前AD。
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来源期刊
CiteScore
3.20
自引率
4.50%
发文量
52
审稿时长
6-12 weeks
期刊介绍: Journal of Clinical and Experimental Neuropsychology ( JCEN) publishes research on the neuropsychological consequences of brain disease, disorders, and dysfunction, and aims to promote the integration of theories, methods, and research findings in clinical and experimental neuropsychology. The primary emphasis of JCEN is to publish original empirical research pertaining to brain-behavior relationships and neuropsychological manifestations of brain disease. Theoretical and methodological papers, critical reviews of content areas, and theoretically-relevant case studies are also welcome.
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