Obstetric complications and clinical presentation in first episode of psychosis.

IF 3.8 4区 医学 Q1 Medicine Acta Neuropsychiatrica Pub Date : 2023-06-01 DOI:10.1017/neu.2023.9
Norma Verdolini, Gisela Mezquida, Isabel Valli, Clemente Garcia-Rizo, Manuel Cuesta, Eduard Vieta, Miquel Bioque, Antonio Lobo, Ana González-Pinto, Laura Pina-Camacho, Iluminada Corripio, Marina Garriga, Inmaculada Baeza, Laura Martínez-Sadurní, Byron Bitanihirwe, Mary Cannon, Miquel Bernardo
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引用次数: 1

Abstract

Objective: Psychotic disorders exhibit a complex aetiology that combines genetic and environmental factors. Among the latter, obstetric complications (OCs) have been widely studied as risk factors, but it is not yet well understood how OCs relate to the heterogeneous presentations of psychotic disorders. We assessed the clinical phenotypes of individuals with a first episode of psychosis (FEP) in relation to the presence of OCs.

Methods: Two-hundred seventy-seven patients with an FEP were assessed for OCs using the Lewis-Murray scale, with data stratified into three subscales depending on the timing and the characteristics of the obstetric event, namely: complications of pregnancy, abnormal foetal growth and development and difficulties in delivery. We also considered other two groups: any complications during the pregnancy period and all OCs taken altogether. Patients were clinically evaluated with the Positive and Negative Syndrome Scale for schizophrenia.

Results: Total OCs and difficulties in delivery were related to more severe psychopathology, and this remained significant after co-varying for age, sex, traumatic experiences, antipsychotic dosage and cannabis use.

Conclusions: Our results highlight the relevance of OCs for the clinical presentation of psychosis. Describing the timing of the OCs is essential in understanding the heterogeneity of the clinical presentation.

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精神病首发的产科并发症与临床表现。
目的:精神障碍表现出复杂的病因,包括遗传和环境因素。在后者中,产科并发症(OCs)作为危险因素已被广泛研究,但尚不清楚OCs如何与精神障碍的异质性表现相关联。我们评估了与OCs存在相关的首发精神病(FEP)个体的临床表型。方法:采用Lewis-Murray量表对277例FEP患者的OCs进行评估,并根据时间和产科事件的特征将数据分为三个亚量表,即:妊娠并发症、胎儿生长发育异常和分娩困难。我们还考虑了另外两组:妊娠期间的任何并发症和所有的OCs。采用精神分裂症阳性和阴性症状量表对患者进行临床评价。结果:总OCs和分娩困难与更严重的精神病理有关,并且在年龄、性别、创伤经历、抗精神病药物剂量和大麻使用共变后,这一点仍然显著。结论:我们的研究结果强调了OCs与精神病临床表现的相关性。描述OCs发生的时间对于理解临床表现的异质性至关重要。
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来源期刊
Acta Neuropsychiatrica
Acta Neuropsychiatrica 医学-精神病学
CiteScore
8.50
自引率
5.30%
发文量
30
审稿时长
6-12 weeks
期刊介绍: Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.
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