Polysaccharides Derived from Mushrooms in Immune and Antitumor Activity: A Review.

IF 1.4 4区 生物学 Q4 MYCOLOGY International journal of medicinal mushrooms Pub Date : 2023-01-01 DOI:10.1615/IntJMedMushrooms.2023049062
Yating Dong, Tao Wang, Jin Zhao, Bingcheng Gan, Rencai Feng, Renyun Miao
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Abstract

Mushrooms are full of nutrition and have beneficial properties for human health. Polysaccharides are the main component of edible and medicinal mushrooms, especially β-glucans, which have attracted much more attention for their complex structure and diverse biological activities. Among all the diverse medicinal activities of mushroom polysaccharides, antitumor and immune-enhancing activities are two excellent bioactivities that have much more potential and deserve application. Their bioactivities are highly dependent on their structural features, including molecular weight, monosaccharide composition, degree of branching, type and configuration of glycosidic bonds, substituent pattern, and chain conformation. This review summarizes the current method for obtaining polysaccharides from mushrooms, chemical characterizations of the structures and their roles in immune and antitumor activities. In addition, the methods for preparation of the polysaccharide derivatives and the potential medicinal clinical application are also discussed in this review, which may provide new guidance for mushroom polysaccharide development.

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蘑菇多糖的免疫和抗肿瘤活性研究进展
蘑菇营养丰富,对人体健康有益。多糖是食用菌和药用菌的主要成分,其中β-葡聚糖因其复杂的结构和多样的生物活性而备受关注。在香菇多糖的多种药用活性中,抗肿瘤活性和免疫增强活性是两种极具应用潜力的生物活性。它们的生物活性高度依赖于它们的结构特征,包括分子量、单糖组成、分支程度、糖苷键的类型和构型、取代基模式和链构象。本文综述了目前从蘑菇中提取多糖的方法、结构的化学性质及其在免疫和抗肿瘤中的作用。此外,本文还对其衍生物的制备方法及潜在的药用临床应用进行了综述,以期为香菇多糖的开发提供新的指导。
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来源期刊
CiteScore
2.60
自引率
16.70%
发文量
91
审稿时长
6-12 weeks
期刊介绍: The rapid growth of interest in medicinal mushrooms research is matched by the large number of disparate groups that currently publish in a wide range of publications. The International Journal of Medicinal Mushrooms is the one source of information that will draw together all aspects of this exciting and expanding field - a source that will keep you up to date with the latest issues and practice. The International Journal of Medicinal Mushrooms published original research articles and critical reviews on a broad range of subjects pertaining to medicinal mushrooms, including systematics, nomenclature, taxonomy, morphology, medicinal value, biotechnology, and much more.
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