Aerobic Training Increases Hippocampal Volume and Protects Cognitive Function for Type 2 Diabetes Patients with Normal Cognition.

IF 1.6 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-11-01 Epub Date: 2023-06-02 DOI:10.1055/a-2105-0799
Ying Wang, Liping Wang, Juan Yan, Xiaodan Yuan, Qing Q Lou
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Abstract

Aim: To evaluate the effects of aerobic training on hippocampal volume and cognitive function in patients with type 2 diabetes mellitus (T2DM) with normal cognition.

Materials and methods: One hundred patients with T2DM aged 60-75 years who met inclusion criteria were randomized into the aerobic training group (n=50) and control group (n=50). The aerobic training group received 1 year of aerobic training, while the control group maintained their lifestyle without additional exercise intervention. The primary outcomes were hippocampal volume measured by MRI and Mini-mental State Examination (MMSE) score or Montreal Cognitive Assessment scale (MoCA) scores.

Results: Eighty-two participants completed the study (aerobic training group, n=40; control group, n=42). There was no significant difference between the two groups at baseline (P>0.05). After one year of moderate aerobic training, increase in total and right hippocampal volume in the aerobic training group were significantly higher than in the control group (P=0.027, P=0.043, respectively). In the aerobic group, total hippocampal volume significantly increased after the intervention compared with baseline (P=0.034). The between-group difference in the change of MMSE and MoCA scores was statistically significant (P=0.015, P=0.027, respectively). Logistic regression showed strong correlations between aerobic training and increase in total hippocampal volume (OR:1.091, [95%CI 0.969, 1.228], P=0.002), improvement of MMSE scores (OR:1.127, [95%CI 1.005, 1.263], P=0.041) or MoCA scores (OR:2.564, [95%CI 2.098.2.973], P=0.045).

Conclusions: One-year moderate aerobic training increased total and right hippocampal volume and protected cognitive function for T2DM patients with normal cognition. Early intervention focusing on cognition protection should be considered for T2DM patients in clinical settings.

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有氧训练增加认知正常的2型糖尿病患者海马体积并保护认知功能。
目的:探讨有氧训练对认知正常的2型糖尿病(T2DM)患者海马体积和认知功能的影响。材料与方法:将100例60 ~ 75岁符合入选标准的T2DM患者随机分为有氧训练组(n=50)和对照组(n=50)。有氧训练组接受1年的有氧训练,而对照组保持原有的生活方式,不进行额外的运动干预。主要结果是MRI测量的海马体积和迷你精神状态检查(MMSE)评分或蒙特利尔认知评估量表(MoCA)评分。结果:82名参与者完成了研究(有氧训练组,n=40;对照组,n=42)。两组在基线时差异无统计学意义(P < 0.05)。适度有氧训练1年后,有氧训练组海马总体积和右侧体积的增加显著高于对照组(P=0.027, P=0.043)。有氧组干预后海马总体积较基线显著增加(P=0.034)。MMSE、MoCA评分组间差异有统计学意义(P=0.015, P=0.027)。Logistic回归结果显示,有氧训练与海马总容积增加(OR:1.091, [95%CI 0.969, 1.228], P=0.002)、MMSE评分改善(OR:1.127, [95%CI 1.005, 1.263], P=0.041)、MoCA评分改善(OR:2.564, [95%CI 2.098.2.973], P=0.045)之间存在较强相关性。结论:1年适度有氧训练可使认知正常的T2DM患者海马总体积和右侧体积增加,保护认知功能。临床应考虑以认知保护为主的早期干预。
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来源期刊
CiteScore
4.10
自引率
5.60%
发文量
72
审稿时长
3 months
期刊介绍: Publishing outstanding articles from all fields of endocrinology and diabetology, from molecular biology to clinical research, this journal is a brilliant resource. Since being published in English in 1983, the popularity of this journal has grown steadily, reflecting the importance of this publication within its field. Original contributions and short communications appear in each issue along with reviews addressing current topics. In addition, supplementary issues are published each year presenting abstracts or proceedings of national and international scientific meetings. The journal was initially published in German and is still the oldest endocrinological periodical in the German-language market!
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