艾滋病毒感染者的人体微生物组和肠道-肝脏轴。

IF 3.7 2区 医学 Q2 INFECTIOUS DISEASES Current HIV/AIDS Reports Pub Date : 2023-06-01 Epub Date: 2023-05-02 DOI:10.1007/s11904-023-00657-x
Maria J Duarte, Phyllis C Tien, Ma Somsouk, Jennifer C Price
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引用次数: 0

摘要

审查目的:慢性肝病是艾滋病病毒感染者(PLWH)发病和死亡的主要原因。新出现的数据表明,肠道微生物转位可能在驱动和调节肝脏疾病方面发挥作用,这种双向关系被称为肠道-肝脏轴。虽然人们认识到 PLWH 存在严重的菌群失调和肠道微生物转位,但对 PLWH 的肠道-肝脏轴却知之甚少:最近的研究表明,微生物易位可直接导致肝脏炎症,并将 PLWH 的肠道微生物特征、菌群失调和易位与肝脏疾病联系起来。此外,多项试验还探索了针对 PLWH 微生物群的干预措施。新近的研究证实,在 PLWH 患者中,肠道微生物组与肝病之间存在相互作用。这为我们进一步了解该人群肝病的病理生理学以及探索可能的临床干预措施提供了新的机遇。
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The human microbiome and gut-liver axis in people living with HIV.

Purpose of review: Chronic liver disease is a major cause of morbidity and mortality amongst people living with HIV (PLWH). Emerging data suggests that gut microbial translocation may play a role in driving and modulating liver disease, a bi-directional relationship termed the gut-liver axis. While it is recognized that PLWH have a high degree of dysbiosis and gut microbial translocation, little is known about the gut-liver axis in PLWH.

Recent findings: Recent studies have shown that microbial translocation can directly lead to hepatic inflammation, and have linked gut microbial signatures, dysbiosis, and translocation to liver disease in PLWH. Additionally, multiple trials have explored interventions targeting the microbiome in PLWH. Emerging research supports the interaction between the gut microbiome and liver disease in PLWH. This offers new opportunities to expand our understanding of the pathophysiology of liver disease in this population, as well as to explore possible clinical interventions.

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来源期刊
Current HIV/AIDS Reports
Current HIV/AIDS Reports INFECTIOUS DISEASES-
CiteScore
8.10
自引率
2.20%
发文量
45
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of HIV/AIDS. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antiretroviral therapies, behavioral aspects of management, and metabolic complications and comorbidity. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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