CD36基因多态性和唾液信号与油酸敏感性和饮食脂肪摄入有关。

IF 2.7 4区 医学 Q3 NUTRITION & DIETETICS Nutrition Bulletin Pub Date : 2023-09-01 Epub Date: 2023-08-03 DOI:10.1111/nbu.12633
Karthi Muthuswamy, Deepankumar Shanmugamprema, Gowtham Subramanian, Vinithra Ponnusamy, Keerthana Vasanthakumar, Vasanth Krishnan, Praveen Raj Palanivelu, Senthilkumar Rajasekaran, Selvakumar Subramaniam
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引用次数: 0

摘要

缺乏对遗传变异(特别是CD36 SNPs-rs1761667和rs1527483)、饮食习惯(是否素食)和唾液环境对肥胖和味觉敏感的综合影响的研究,尤其是在印度人群中。目前的研究旨在通过检测印度参与者中CD36 SNPs、油酸(OA)检测阈值和饮食习惯之间的联合关系,更好地了解味觉受损、脂肪消耗、较高BMI和肥胖发展之间的关系。此外,还考虑了口腔脂肪酸(FA)敏感性与炎症和唾液蛋白相关的味觉生理因素之间的关系。具有CD36小等位基因(AA/AG)的参与者(在rs1527483和rs1761667中)消耗了更多的脂肪,尤其是饱和脂肪酸(p = 引起炎症的唾液脂多糖在BMI较高的非素食者中显著增加(p  25 kg/m2具有显著较高的TNF-α和IL-6受体mRNA表达水平,但素食组和非素食组之间没有显著差异。然而,唾液中对口腔环境具有缓冲能力的CA-VI在患有BMI的非素食成年人中较低 >25.因此,研究表明,印度超重和肥胖的非素食者属于CD36 SNP的高危人群(AA/AG为rs1761667和rs1527483),并且具有较高水平的炎症标志物,这加剧了食物行为和生理变化的改变,表明它们与肥胖的发展有关。
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CD36 genetic polymorphism and salivary cues are associated with oleic acid sensitivity and dietary fat intake.

There is a lack of research on the combined effects of genetic variations (specifically CD36 SNPs-rs1761667 and rs1527483), dietary food habits (vegetarian or not), and the salivary environment on obesity and taste sensitivity, especially in the Indian population. The current study aims to better understand the relationship between impaired taste perception, fat consumption, higher BMI and obesity development by examining the combined association between CD36 SNPs, oleic acid (OA) detection threshold, and food habits among Indian participants. Furthermore, the relationship between oral fatty acid (FAs) sensitivity and taste physiology factors linked to inflammation and salivary proteins was considered. Participants with the minor allele (AA/AG) of CD36 (in both rs1527483 and rs1761667) consumed more fat, particularly saturated FAs (p = 0.0351). Salivary lipopolysaccharide, which causes inflammation, was significantly greater in non-vegetarians with a higher BMI (p < 0.05), and it exhibited a negative correlation (r = -0.232 and p < 0.05) with Ki67 gene expression, a marker for taste progenitor cells. A positive correlation (r = 0.474, p = 0.04) between TLR4 mRNA levels and the OA detection threshold was also observed. Participants with BMI > 25 kg/m2 had substantially higher TNF-α and IL-6 receptor mRNA expression levels, but there were no significant differences between the vegetarian and non-vegetarian groups. However, salivary CA-VI, which has a buffering capability on the oral environment, was lower in non-vegetarian adults with BMI >25. Thus, it was shown that non-vegetarians with overweight and obesity in India were in at-risk groups for the CD36 SNP (AA/AG at rs1761667 and rs1527483) and had higher levels of inflammatory markers, which exacerbated alterations in food behaviour and physiological changes, indicating their relevance in the development of obesity.

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来源期刊
Nutrition Bulletin
Nutrition Bulletin NUTRITION & DIETETICS-
CiteScore
4.50
自引率
12.10%
发文量
58
期刊介绍: The Nutrition Bulletin provides accessible reviews at the cutting edge of research. Read by researchers and nutritionists working in universities and research institutes; public health nutritionists, dieticians and other health professionals; nutritionists, technologists and others in the food industry; those engaged in higher education including students; and journalists with an interest in nutrition.
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