4种罕见的临床真菌，Lodderomyces elongisporus, Kodamaea ohmeri, Cyberlindnera fabianii和Wickerhamomyces anomalus，从Côte d’ivire的表层样品中分离得到

IF 2.2 4区医学 Q3 MYCOLOGY Journal de mycologie medicale Pub Date : 2023-08-01 DOI:10.1016/j.mycmed.2023.101410

Ama Valérie Bonouman Ira , Donika Krasteva , Francis Kouadjo , Fréderic Roger , Virginie Bellet , David Koffi , Cyrille Pottier , Offianan André Toure , Pascal Drakulovski , Aliko Joseph Djaman , Stéphane Ranque , Sébastien Bertout

{"title":"4种罕见的临床真菌，Lodderomyces elongisporus, Kodamaea ohmeri, Cyberlindnera fabianii和Wickerhamomyces anomalus，从Côte d’ivire的表层样品中分离得到","authors":"Ama Valérie Bonouman Ira , Donika Krasteva , Francis Kouadjo , Fréderic Roger , Virginie Bellet , David Koffi , Cyrille Pottier , Offianan André Toure , Pascal Drakulovski , Aliko Joseph Djaman , Stéphane Ranque , Sébastien Bertout","doi":"10.1016/j.mycmed.2023.101410","DOIUrl":null,"url":null,"abstract":"<div><h3>Aims</h3><p>The rare yeast species <span><em>Lodderomyces elongisporus, Kodamaea ohmeri, </em><em>Cyberlindnera</em><em> fabianii,</em></span> and <span><em>Wickerhamomyces anomalus</em></span><span> are increasingly implicated in severe mycoses<span> in immunocompromised patients. This study aimed to assess the prevalence of uncommon yeast species in Côte d'Ivoire.</span></span></p></div><div><h3>Methods</h3><p>The yeast isolates from superficial samples, mainly vaginal swabs, were collected at the Pasteur Institute of Abidjan in a study on the molecular epidemiology<span> of clinical yeast species. Identification relied on MALDI-TOF MS and ITS sequence analysis. Antifungal susceptibility testing was performed using the CLSI method.</span></p></div><div><h3>Results</h3><p>Of the 315 strains analysed from 227 outpatients, 14 belonged to 4 uncommon species: <em>Lodderomyces elongisporus, Kodamaea ohmeri, Cyberlindnera fabianii,</em> and <em>Wickerhamomyces anomalus</em><span><span><span>. None exhibited elevated fluconazole, </span>amphotericin B, </span>caspofungin, ketoconazole, or flucytosin MIC.</span></p></div><div><h3>Conclusions</h3><p>The presence of these rare yeasts represents a risk in immunocompromised people. Their adequate and timely identification is a priority. Overall, enhancing the mycoses diagnostic capacities in Côte d'Ivoire, and more generally in African clinical laboratories with limited resources is a critical aim.</p></div>","PeriodicalId":14824,"journal":{"name":"Journal de mycologie medicale","volume":null,"pages":null},"PeriodicalIF":2.2000,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Four uncommon clinical fungi, Lodderomyces elongisporus, Kodamaea ohmeri, Cyberlindnera fabianii and Wickerhamomyces anomalus, isolated in superficial samples from Côte d'Ivoire\",\"authors\":\"Ama Valérie Bonouman Ira , Donika Krasteva , Francis Kouadjo , Fréderic Roger , Virginie Bellet , David Koffi , Cyrille Pottier , Offianan André Toure , Pascal Drakulovski , Aliko Joseph Djaman , Stéphane Ranque , Sébastien Bertout\",\"doi\":\"10.1016/j.mycmed.2023.101410\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Aims</h3><p>The rare yeast species <span><em>Lodderomyces elongisporus, Kodamaea ohmeri, </em><em>Cyberlindnera</em><em> fabianii,</em></span> and <span><em>Wickerhamomyces anomalus</em></span><span> are increasingly implicated in severe mycoses<span> in immunocompromised patients. This study aimed to assess the prevalence of uncommon yeast species in Côte d'Ivoire.</span></span></p></div><div><h3>Methods</h3><p>The yeast isolates from superficial samples, mainly vaginal swabs, were collected at the Pasteur Institute of Abidjan in a study on the molecular epidemiology<span> of clinical yeast species. Identification relied on MALDI-TOF MS and ITS sequence analysis. Antifungal susceptibility testing was performed using the CLSI method.</span></p></div><div><h3>Results</h3><p>Of the 315 strains analysed from 227 outpatients, 14 belonged to 4 uncommon species: <em>Lodderomyces elongisporus, Kodamaea ohmeri, Cyberlindnera fabianii,</em> and <em>Wickerhamomyces anomalus</em><span><span><span>. None exhibited elevated fluconazole, </span>amphotericin B, </span>caspofungin, ketoconazole, or flucytosin MIC.</span></p></div><div><h3>Conclusions</h3><p>The presence of these rare yeasts represents a risk in immunocompromised people. Their adequate and timely identification is a priority. Overall, enhancing the mycoses diagnostic capacities in Côte d'Ivoire, and more generally in African clinical laboratories with limited resources is a critical aim.</p></div>\",\"PeriodicalId\":14824,\"journal\":{\"name\":\"Journal de mycologie medicale\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2023-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal de mycologie medicale\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1156523323000549\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MYCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal de mycologie medicale","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1156523323000549","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MYCOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

目的稀有酵母Lodderomyces elongisporus、Kodamaea ohmeri、Cyberlindera fabianii和Wickehamomyces anomalus越来越多地与免疫功能受损患者的严重真菌病有关。这项研究旨在评估科特迪瓦罕见酵母物种的流行情况。方法在阿比让巴斯德研究所收集浅表样本中的酵母分离株，主要是阴道拭子，对临床酵母种类的分子流行病学进行研究。鉴定依赖于MALDI-TOF MS及其序列分析。使用CLSI方法进行抗真菌药敏试验。结果在227例门诊病人的315株菌株中，14株属于4个不常见的菌种：Lodderomyces elongisporus、Kodamaea ohmeri、Cyberlindera fabianii和Wickehamomyces anomalus。氟康唑、两性霉素B、卡泊芬净、酮康唑或氟康唑MIC均未升高。结论这些罕见酵母的存在代表了免疫功能低下人群的风险。充分和及时地查明他们的身份是一个优先事项。总的来说，在资源有限的情况下，提高科特迪瓦以及更广泛的非洲临床实验室的真菌病诊断能力是一个关键目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Four uncommon clinical fungi, Lodderomyces elongisporus, Kodamaea ohmeri, Cyberlindnera fabianii and Wickerhamomyces anomalus, isolated in superficial samples from Côte d'Ivoire

Aims

The rare yeast species Lodderomyces elongisporus, Kodamaea ohmeri, Cyberlindnera fabianii, and Wickerhamomyces anomalus are increasingly implicated in severe mycoses in immunocompromised patients. This study aimed to assess the prevalence of uncommon yeast species in Côte d'Ivoire.

Methods

The yeast isolates from superficial samples, mainly vaginal swabs, were collected at the Pasteur Institute of Abidjan in a study on the molecular epidemiology of clinical yeast species. Identification relied on MALDI-TOF MS and ITS sequence analysis. Antifungal susceptibility testing was performed using the CLSI method.

Results

Of the 315 strains analysed from 227 outpatients, 14 belonged to 4 uncommon species: Lodderomyces elongisporus, Kodamaea ohmeri, Cyberlindnera fabianii, and Wickerhamomyces anomalus. None exhibited elevated fluconazole, amphotericin B, caspofungin, ketoconazole, or flucytosin MIC.

Conclusions

The presence of these rare yeasts represents a risk in immunocompromised people. Their adequate and timely identification is a priority. Overall, enhancing the mycoses diagnostic capacities in Côte d'Ivoire, and more generally in African clinical laboratories with limited resources is a critical aim.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal de mycologie medicale 医学-真菌学

CiteScore

5.10

自引率

2.80%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal de Mycologie Medicale / Journal of Medical Mycology (JMM) publishes in English works dealing with human and animal mycology. The subjects treated are focused in particular on clinical, diagnostic, epidemiological, immunological, medical, pathological, preventive or therapeutic aspects of mycoses. Also covered are basic aspects linked primarily with morphology (electronic and photonic microscopy), physiology, biochemistry, cellular and molecular biology, immunochemistry, genetics, taxonomy or phylogeny of pathogenic or opportunistic fungi and actinomycetes in humans or animals. Studies of natural products showing inhibitory activity against pathogenic fungi cannot be considered without chemical characterization and identification of the compounds responsible for the inhibitory activity. JMM publishes (guest) editorials, original articles, reviews (and minireviews), case reports, technical notes, letters to the editor and information. Only clinical cases with real originality (new species, new clinical present action, new geographical localization, etc.), and fully documented (identification methods, results, etc.), will be considered. Under no circumstances does the journal guarantee publication before the editorial board makes its final decision. The journal is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey platforms.