Ahmed H Eissa, Asmaa M Abdel-Tawab, Fawzia Z El-Ablack, Seif-Eldin N Ayyad
{"title":"红海软珊瑚Dendronephthya spp中两个新的芳香a环甾体的细胞毒性和抗菌评价。","authors":"Ahmed H Eissa, Asmaa M Abdel-Tawab, Fawzia Z El-Ablack, Seif-Eldin N Ayyad","doi":"10.1080/14786419.2023.2254452","DOIUrl":null,"url":null,"abstract":"<p><p>A successful column chromatography of a CHCl<sub>3</sub>/MeOH crude extract of <i>Dendronephthya spp.</i> soft coral led to the isolation of two new aromatic A-ring steroids (<b>1-2</b>), together with three known compounds (<b>3-5</b>). Both <b>1</b> and <b>2</b> are 19-norsteroids. The chemical structures were elucidated based on extensive 1D, 2D NMR, and EIMS analyses. In cytotoxic bioassays, compounds <b>1-5</b> were tested against three cancer cell lines: MCF-7, NCI-1299, and HepG2, with IC<sub>50</sub> in the ranges of 22.1-85.4, 26.9-88.7, and 25.9-93.7 <i>μ</i>M, respectively. Compounds <b>1</b>, <b>2</b>, and <b>5</b> showed moderate degrees of inhibition against <i>Escherichia coli</i> and <i>Pseudomonas sp.</i> at 100 and 150 <i>µ</i>g/mL, while exhibiting weak inhibition against <i>Bacillus cereus</i> and <i>Staphylococcus aureus</i> at 150 <i>µ</i>g/mL.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"94-102"},"PeriodicalIF":1.9000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cytotoxic and anti-bacterial evaluation of two new aromatic A-ring steroids isolated from the Red Sea soft coral <i>Dendronephthya spp.</i>\",\"authors\":\"Ahmed H Eissa, Asmaa M Abdel-Tawab, Fawzia Z El-Ablack, Seif-Eldin N Ayyad\",\"doi\":\"10.1080/14786419.2023.2254452\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A successful column chromatography of a CHCl<sub>3</sub>/MeOH crude extract of <i>Dendronephthya spp.</i> soft coral led to the isolation of two new aromatic A-ring steroids (<b>1-2</b>), together with three known compounds (<b>3-5</b>). Both <b>1</b> and <b>2</b> are 19-norsteroids. The chemical structures were elucidated based on extensive 1D, 2D NMR, and EIMS analyses. In cytotoxic bioassays, compounds <b>1-5</b> were tested against three cancer cell lines: MCF-7, NCI-1299, and HepG2, with IC<sub>50</sub> in the ranges of 22.1-85.4, 26.9-88.7, and 25.9-93.7 <i>μ</i>M, respectively. Compounds <b>1</b>, <b>2</b>, and <b>5</b> showed moderate degrees of inhibition against <i>Escherichia coli</i> and <i>Pseudomonas sp.</i> at 100 and 150 <i>µ</i>g/mL, while exhibiting weak inhibition against <i>Bacillus cereus</i> and <i>Staphylococcus aureus</i> at 150 <i>µ</i>g/mL.</p>\",\"PeriodicalId\":18990,\"journal\":{\"name\":\"Natural Product Research\",\"volume\":\" \",\"pages\":\"94-102\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Product Research\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1080/14786419.2023.2254452\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/9/4 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2023.2254452","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/9/4 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Cytotoxic and anti-bacterial evaluation of two new aromatic A-ring steroids isolated from the Red Sea soft coral Dendronephthya spp.
A successful column chromatography of a CHCl3/MeOH crude extract of Dendronephthya spp. soft coral led to the isolation of two new aromatic A-ring steroids (1-2), together with three known compounds (3-5). Both 1 and 2 are 19-norsteroids. The chemical structures were elucidated based on extensive 1D, 2D NMR, and EIMS analyses. In cytotoxic bioassays, compounds 1-5 were tested against three cancer cell lines: MCF-7, NCI-1299, and HepG2, with IC50 in the ranges of 22.1-85.4, 26.9-88.7, and 25.9-93.7 μM, respectively. Compounds 1, 2, and 5 showed moderate degrees of inhibition against Escherichia coli and Pseudomonas sp. at 100 and 150 µg/mL, while exhibiting weak inhibition against Bacillus cereus and Staphylococcus aureus at 150 µg/mL.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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