Jiahao Zhu, Dan Zhou, Yaoyao Nie, Jing Wang, Ye Yang, Dingwan Chen, Min Yu, Yingjun Li
{"title":"虚弱和抑郁之间双向因果关系的评估:一项孟德尔随机化研究。","authors":"Jiahao Zhu, Dan Zhou, Yaoyao Nie, Jing Wang, Ye Yang, Dingwan Chen, Min Yu, Yingjun Li","doi":"10.1002/jcsm.13319","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Observational studies have demonstrated a strong bidirectional association between frailty and depression, but it remains unclear whether this association reflects causality. This study aimed to examine the bidirectional causal relationship between frailty and depression.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Using genome-wide association study summary data, two-sample Mendelian randomization was performed to test for the potential bidirectional causality between frailty, as defined by both the frailty index and the frailty phenotype, and depression. Several frailty-related traits were additionally investigated, including weaker hand grip strength, slower walking pace and physical inactivity. Findings were replicated using an independent depression data source and verified using multiple sensitivity analyses.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Genetically predicted higher frailty index (odds ratio [OR], 1.86; <i>P</i> < 0.001), higher frailty phenotype score (OR, 2.79; <i>P</i> < 0.001), lower grip strength (OR, 1.23; <i>P</i> = 0.003), slower walking pace (OR, 1.55; <i>P</i> = 0.027) and physical inactivity (OR, 1.44; <i>P</i> = 0.003) all were associated with a higher risk of depression. As for the reverse direction, genetic liability to depression showed consistent associations with a higher frailty index (beta, 0.167; <i>P</i> < 0.001) and a higher frailty phenotype score (beta, 0.067; <i>P</i> = 0.001), but not with other frailty-related traits that were investigated. The results were stable across sensitivity analyses and across depression datasets.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Our findings add novel evidence supporting the bidirectional causal association between frailty and depression. Improving balance and muscle strength and increasing physical activity may be beneficial in both depression and frailty.</p>\n </section>\n </div>","PeriodicalId":186,"journal":{"name":"Journal of Cachexia, Sarcopenia and Muscle","volume":null,"pages":null},"PeriodicalIF":8.9000,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcsm.13319","citationCount":"0","resultStr":"{\"title\":\"Assessment of the bidirectional causal association between frailty and depression: A Mendelian randomization study\",\"authors\":\"Jiahao Zhu, Dan Zhou, Yaoyao Nie, Jing Wang, Ye Yang, Dingwan Chen, Min Yu, Yingjun Li\",\"doi\":\"10.1002/jcsm.13319\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Observational studies have demonstrated a strong bidirectional association between frailty and depression, but it remains unclear whether this association reflects causality. This study aimed to examine the bidirectional causal relationship between frailty and depression.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Using genome-wide association study summary data, two-sample Mendelian randomization was performed to test for the potential bidirectional causality between frailty, as defined by both the frailty index and the frailty phenotype, and depression. Several frailty-related traits were additionally investigated, including weaker hand grip strength, slower walking pace and physical inactivity. Findings were replicated using an independent depression data source and verified using multiple sensitivity analyses.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Genetically predicted higher frailty index (odds ratio [OR], 1.86; <i>P</i> < 0.001), higher frailty phenotype score (OR, 2.79; <i>P</i> < 0.001), lower grip strength (OR, 1.23; <i>P</i> = 0.003), slower walking pace (OR, 1.55; <i>P</i> = 0.027) and physical inactivity (OR, 1.44; <i>P</i> = 0.003) all were associated with a higher risk of depression. As for the reverse direction, genetic liability to depression showed consistent associations with a higher frailty index (beta, 0.167; <i>P</i> < 0.001) and a higher frailty phenotype score (beta, 0.067; <i>P</i> = 0.001), but not with other frailty-related traits that were investigated. The results were stable across sensitivity analyses and across depression datasets.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>Our findings add novel evidence supporting the bidirectional causal association between frailty and depression. 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Assessment of the bidirectional causal association between frailty and depression: A Mendelian randomization study
Background
Observational studies have demonstrated a strong bidirectional association between frailty and depression, but it remains unclear whether this association reflects causality. This study aimed to examine the bidirectional causal relationship between frailty and depression.
Methods
Using genome-wide association study summary data, two-sample Mendelian randomization was performed to test for the potential bidirectional causality between frailty, as defined by both the frailty index and the frailty phenotype, and depression. Several frailty-related traits were additionally investigated, including weaker hand grip strength, slower walking pace and physical inactivity. Findings were replicated using an independent depression data source and verified using multiple sensitivity analyses.
Results
Genetically predicted higher frailty index (odds ratio [OR], 1.86; P < 0.001), higher frailty phenotype score (OR, 2.79; P < 0.001), lower grip strength (OR, 1.23; P = 0.003), slower walking pace (OR, 1.55; P = 0.027) and physical inactivity (OR, 1.44; P = 0.003) all were associated with a higher risk of depression. As for the reverse direction, genetic liability to depression showed consistent associations with a higher frailty index (beta, 0.167; P < 0.001) and a higher frailty phenotype score (beta, 0.067; P = 0.001), but not with other frailty-related traits that were investigated. The results were stable across sensitivity analyses and across depression datasets.
Conclusions
Our findings add novel evidence supporting the bidirectional causal association between frailty and depression. Improving balance and muscle strength and increasing physical activity may be beneficial in both depression and frailty.
期刊介绍:
The Journal of Cachexia, Sarcopenia, and Muscle is a prestigious, peer-reviewed international publication committed to disseminating research and clinical insights pertaining to cachexia, sarcopenia, body composition, and the physiological and pathophysiological alterations occurring throughout the lifespan and in various illnesses across the spectrum of life sciences. This journal serves as a valuable resource for physicians, biochemists, biologists, dieticians, pharmacologists, and students alike.