虚弱和抑郁之间双向因果关系的评估:一项孟德尔随机化研究。

IF 8.9 1区 医学 Journal of Cachexia, Sarcopenia and Muscle Pub Date : 2023-09-05 DOI:10.1002/jcsm.13319
Jiahao Zhu, Dan Zhou, Yaoyao Nie, Jing Wang, Ye Yang, Dingwan Chen, Min Yu, Yingjun Li
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引用次数: 0

摘要

背景:观察性研究表明,虚弱和抑郁之间存在强烈的双向关联,但尚不清楚这种关联是否反映了因果关系。本研究旨在检验虚弱和抑郁之间的双向因果关系。方法:使用全基因组关联研究总结数据,进行两个样本的孟德尔随机化,以测试虚弱指数和虚弱表型定义的虚弱与抑郁之间的潜在双向因果关系。另外还研究了一些与虚弱相关的特征,包括握力较弱、行走速度较慢和身体不活动。使用独立的抑郁症数据源复制研究结果,并使用多重敏感性分析进行验证。结果:基因预测更高的虚弱指数(比值比[OR],1.86;P结论:我们的研究结果为支持虚弱和抑郁之间的双向因果关系提供了新的证据。改善平衡和肌肉力量以及增加体力活动可能对抑郁和虚弱都有益。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Assessment of the bidirectional causal association between frailty and depression: A Mendelian randomization study

Background

Observational studies have demonstrated a strong bidirectional association between frailty and depression, but it remains unclear whether this association reflects causality. This study aimed to examine the bidirectional causal relationship between frailty and depression.

Methods

Using genome-wide association study summary data, two-sample Mendelian randomization was performed to test for the potential bidirectional causality between frailty, as defined by both the frailty index and the frailty phenotype, and depression. Several frailty-related traits were additionally investigated, including weaker hand grip strength, slower walking pace and physical inactivity. Findings were replicated using an independent depression data source and verified using multiple sensitivity analyses.

Results

Genetically predicted higher frailty index (odds ratio [OR], 1.86; P < 0.001), higher frailty phenotype score (OR, 2.79; P < 0.001), lower grip strength (OR, 1.23; P = 0.003), slower walking pace (OR, 1.55; P = 0.027) and physical inactivity (OR, 1.44; P = 0.003) all were associated with a higher risk of depression. As for the reverse direction, genetic liability to depression showed consistent associations with a higher frailty index (beta, 0.167; P < 0.001) and a higher frailty phenotype score (beta, 0.067; P = 0.001), but not with other frailty-related traits that were investigated. The results were stable across sensitivity analyses and across depression datasets.

Conclusions

Our findings add novel evidence supporting the bidirectional causal association between frailty and depression. Improving balance and muscle strength and increasing physical activity may be beneficial in both depression and frailty.

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来源期刊
Journal of Cachexia, Sarcopenia and Muscle
Journal of Cachexia, Sarcopenia and Muscle Medicine-Orthopedics and Sports Medicine
自引率
12.40%
发文量
0
期刊介绍: The Journal of Cachexia, Sarcopenia, and Muscle is a prestigious, peer-reviewed international publication committed to disseminating research and clinical insights pertaining to cachexia, sarcopenia, body composition, and the physiological and pathophysiological alterations occurring throughout the lifespan and in various illnesses across the spectrum of life sciences. This journal serves as a valuable resource for physicians, biochemists, biologists, dieticians, pharmacologists, and students alike.
期刊最新文献
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