原位凝胶法治疗口腔溃疡的研究进展及评价。

IF 1.8 Q3 PHARMACOLOGY & PHARMACY Turkish Journal of Pharmaceutical Sciences Pub Date : 2023-07-07 DOI:10.4274/tjps.galenos.2022.25968
Nikita Harekrishna Gurav, Prerana Shantinath Husukale
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引用次数: 0

摘要

目的:口腔溃疡是由多种情况引起的最普遍的疾病之一。许多配方,如溶液、悬浮液和软膏在商业上都可以买到。然而,由于没有长期效果,没有任何药物可以被认为是完全有效的治疗口腔溃疡。采用生物黏附的方法可以提高治疗效果。因为它比制备的凝胶制剂更容易施用,所以溶胶-凝胶转化的现象是有益的。本研究的主要目的是开发和测试以水杨酸胆碱和硼砂为模型药物治疗口腔溃疡的原位凝胶。材料和方法:由于在该配方中使用了热敏聚合物,因此从溶胶到凝胶的变化是热可逆的,并且通过使用粘接聚合物carbopol减少了给药频率。测定了凝胶温度、pH值、凝胶强度、涂敷性、体外黏附、体外释药量。结果:实验切片显示,溶胶的粘度和凝胶强度随温度的升高而增加,即由于体温的作用,可以在涂抹部位形成凝胶。当波洛沙姆407浓度为14 ~ 16% w/v时,胶凝温度接近体温(35 ~ 38℃),但当卡波波尔934P加入时,胶凝温度升高。所有配方的pH值在5.5到6.8之间。所有制剂的粘度都小于1000 cps,因此可以简单地给药于口腔溃疡。结论:因此,一种正确研制的口腔溃疡原位凝胶可以延长在应用部位的时间,并尽量减少给药频率。这些发现表明,开发的技术是传统药物输送系统的可行替代方案,可以帮助患者遵守规定。
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Development and Evaluation of In Situ Gel Formation for Treatment of Mouth Ulcer.

Objectives: Mouth ulcers are one of the most prevalent conditions that can be caused by a range of circumstances. Many formulations, such as solutions, suspensions, and ointments are available commercially. However, because there is no long-term effect, no medication can be regarded as totally effective for treating mouth ulcers. The use of bioadhesive methods can boost the therapy efficacy. Because it is easier to administer than prepared gel formulations, the phenomenon of the sol-to-gel conversion can be beneficial. The major goal of this study was to develop and test in situ gels for treating mouth ulcers using choline salicylate and borax as model medicines.

Materials and methods: Because a thermosensitive polymer was employed in this formulation, the sol-to-gel change was thermally reversible, and the frequency of administration was reduced by using the mucoadhesive polymer carbopol. Gelation temperature, pH, gel strength, spreadability, in vitro mucoadhesion, and in vitro drug release were all measured in the formulations.

Results: The experimental section indicated that viscosity of sols and gel strength increased with increasing temperature, i.e., gel can be created at the site of application owing to body temperature. When poloxamer 407 was used at a concentration of 14 to 16 percent w/v, the gelling temperature was close to the body temperature (35-38 °C), but when carbopol 934P was added, the gelling temperature was raised. All formulations had pH between 5.5 and 6.8. All formulations had viscosities of less than 1000 cps, allowing for simple administration of the formulation to a mouth ulcer.

Conclusion: As a result, a correctly developed in situ gel for oral ulcers can extend the duration spent at the application site and minimize the frequency of administration. These findings show that the developed technology is a viable alternative to traditional drug delivery systems and can help patients comply.

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来源期刊
CiteScore
3.60
自引率
5.90%
发文量
79
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