[voxelotor对血红蛋白电泳和色谱谱的影响]。

IF 0.4 4区 医学 Q4 MEDICAL LABORATORY TECHNOLOGY Annales de biologie clinique Pub Date : 2023-07-21 DOI:10.1684/abc.2023.1814
Soraya Fellahi, Nadir Mouri, Baptiste Giraud, Suella Martino, Gonzalo de Luna, Mehdi Sakka, Philippe Joly, Jean-Philippe Bastard, Frédéric Galacteros, Stéphane Moutereau
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引用次数: 0

摘要

Voxelotor (GBT440, OXBRYTA®)最近作为镰状细胞病的可能治疗方法之一出现。这个分子,通过结合血红蛋白的α -珠蛋白,导致后者对氧的高亲和力,并降低其聚合性能。几项治疗试验已经能够显示其对镰状细胞病某些方面的有效性;因此,法国卫生高等管理局(HAS)学院颁发了早期使用许可,自2021年起,可以在临时许可下向患者提供这种治疗。因此,对镰状细胞患者进行生物监测的实验室将面临血红蛋白与GBT440联合存在的新特征。这项工作介绍了通过不同技术获得的图像集合:高效液相色谱,毛细管电泳,等电聚焦,碱性凝胶和酸性琼脂凝胶电泳在输注或非输注镰状细胞病患者。通过这些分析观察到GBT440存在的能力对于表征患者的治疗随访是有用的。
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[Impact of voxelotor on hemoglobin electrophoretic and chromatographic profiles].

Voxelotor (GBT440, OXBRYTA®) appeared recently as one of the possible treatments for sickle cell disease. This molecule, by binding the alpha globin of hemoglobin, causes hyperaffinity of the latter for oxygen and reduces its polymerization properties. Several therapeutic trials have been able to show its effectiveness on certain aspects of sickle cell disease; thus, the french HAS (High Authority of Health) college issued an early access authorization and, since 2021, this treatment can be offered to patients under a temporary authorization for use. Consequently, the laboratories that carry out the biological monitoring of sickle cell patients will be confronted with new profiles characteristic of the presence of hemoglobin combined with GBT440. This work presents a collection of images obtained by different techniques: HPLC, capillary electrophoresis, isoelectrofocusing, alkaline gel and acid agar gel electrophoresis in transfused or non-transfused sickle cell disease patients. The ability to observe the presence of GBT440 by these analyzes could be useful in order to characterize the therapeutic follow-up of patients.

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来源期刊
Annales de biologie clinique
Annales de biologie clinique 医学-医学:研究与实验
CiteScore
0.80
自引率
20.00%
发文量
53
审稿时长
6-12 weeks
期刊介绍: Multidisciplinary information with direct relevance to everyday practice Annales de Biologie Clinique, the official journal of the French Society of Clinical Biology (SFBC), supports biologists in areas including continuing education, laboratory accreditation and technique validation. With original articles, abstracts and accounts of everyday practice, the journal provides details of advances in knowledge, techniques and equipment, as well as a forum for discussion open to the entire community.
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