Mafalda V Moreira, Emídio Vale-Fernandes, Inês C Albergaria, Marco G Alves, Mariana P Monteiro
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引用次数: 0
摘要
多囊卵巢综合征(PCOS)是公认的育龄期女性最常见的内分泌疾病之一。由于患者的辅助生殖技术(ART)效果较差,PCOS已被认为危及卵母细胞质量和能力发育。本系统综述的目的是总结现有的证据,证明接受体外受精(IVF)治疗的多囊卵巢综合征(PCOS)妇女的卵泡液(FF)特征与排卵正常妇女的FF有什么不同。为此,在PubMed和Web of Science数据库中进行了电子搜索(截至2021年12月)。遵循系统评价和荟萃分析首选报告项目- PRISMA指南,并使用纽卡斯尔-渥太华量表评估纳入研究的偏倚风险。从文献中获取的数据(n=42)显示,与未患PCOS的女性相比,PCOS女性的FF组成主要在以下分子类别上存在差异:氧化应激、炎症生物标志物、生长因子和激素。在这些生物标志物中,一些被认为与病理生理过程密切相关,加强了低级别炎症和氧化应激在PCOS发病机制中起关键作用的假设。尽管如此,应该注意的是,PCOS FF指纹的现有数据来自于相对较少的受试者进行的有限数量的研究。此外,多囊卵巢综合征的表型异质性阻碍了更广泛的比较,削弱了推定的结论。因此,未来的研究应侧重于根据表型比较具有良好特征的患者亚组。
Follicular fluid composition and reproductive outcomes of women with polycystic ovary syndrome undergoing in vitro fertilization: A systematic review.
Polycystic ovary syndrome (PCOS) is recognized as one of the most prevalent endocrinopathy in women at reproductive age. As affected women tend to have poorer assisted reproductive technology (ART) outcomes, PCOS has been suggested to endanger oocyte quality and competence development. The aim of this systematic review was to summarize the available evidence on how the follicular fluid (FF) profile of women with PCOS undergoing in vitro fertilization (IVF) treatment differs from the FF of normo-ovulatory women. For that, an electronic search in PubMed and Web of Science databases was conducted (up to December 2021). The Preferred Reporting Items for Systematic Reviews and Meta-Analyses - PRISMA guidelines were followed, and the Newcastle-Ottawa Scale was used to assess the risk of bias in the included studies. Data retrieved from papers included (n=42), revealed that the FF composition of women with PCOS compared to those without PCOS predominantly diverged at the following molecular classes: oxidative stress, inflammatory biomarkers, growth factors and hormones. Among those biomarkers, some were proposed as being closely related to pathophysiological processes, strengthening the hypothesis that low-grade inflammation and oxidative stress play a critical role in the pathogenesis of PCOS. Notwithstanding, it should be noticed that the available data on PCOS FF fingerprints derives from a limited number of studies conducted in a relatively small number of subjects. Furthermore, phenotypic heterogeneity of PCOS hampers wider comparisons and weakens putative conclusions. Therefore, future studies should be focused at comparing well characterized patient subgroups according to phenotypes.
期刊介绍:
Reviews in Endocrine and Metabolic Disorders is an international journal dedicated to the field of endocrinology and metabolism. It aims to provide the latest advancements in this rapidly advancing field to students, clinicians, and researchers. Unlike other journals, each quarterly issue of this review journal focuses on a specific topic and features ten to twelve articles written by world leaders in the field. These articles provide brief overviews of the latest developments, offering insights into both the basic aspects of the disease and its clinical implications. This format allows individuals in all areas of the field, including students, academic clinicians, and practicing clinicians, to understand the disease process and apply their knowledge to their specific areas of interest. The journal also includes selected readings and other essential references to encourage further in-depth exploration of specific topics.