3’端mRNA在顶复门寄生虫内处理,由经典和意想不到的玩家拼凑而成。

IF 6.4 2区 生物学 Q1 CELL BIOLOGY Wiley Interdisciplinary Reviews: RNA Pub Date : 2023-09-01 Epub Date: 2023-03-30 DOI:10.1002/wrna.1783
Christopher Swale, Mohamed-Ali Hakimi
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引用次数: 0

摘要

信使核糖核酸的3’端处理是一个共转录过程,导致信使核糖核酸上形成聚腺苷尾部,并直接控制RNA聚合酶II的终止。这一过程涉及由切割和多腺苷酸化特异性因子(CPSF)组成的百万道尔顿复合物,这些因子能够识别新生信使核糖核酸上的顺式序列元素,然后进行切割和多聚腺苷酸化反应。最近的结构和生物化学研究已经确定了复合物不同亚基所起的作用,并对酵母或后生动物中的这种机制提供了全面的机制理解。最近,在Apicompleta中发现了CPSF功能的小分子抑制剂,这激发了人们对研究这种古老的真核生物机制在这些生物体中的特异性的兴趣。尽管其功能在Apicompleta中是保守的,但CPSF复合物整合了N6-甲基腺苷(m6A)的新读取器。这一特征继承自植物界,将m6A的代谢直接连接到3'-末端加工,并进而连接到转录终止。在这篇综述中,我们将研究CPSF在顶复门寄生虫中的趋同和分化,并探索在这些生物体中小分子抑制这种机制的潜力。本文分类为:RNA加工>3'末端加工RNA加工>RNA编辑和修饰。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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3'-end mRNA processing within apicomplexan parasites, a patchwork of classic, and unexpected players.

The 3'-end processing of mRNA is a co-transcriptional process that leads to the formation of a poly-adenosine tail on the mRNA and directly controls termination of the RNA polymerase II juggernaut. This process involves a megadalton complex composed of cleavage and polyadenylation specificity factors (CPSFs) that are able to recognize cis-sequence elements on nascent mRNA to then carry out cleavage and polyadenylation reactions. Recent structural and biochemical studies have defined the roles played by different subunits of the complex and provided a comprehensive mechanistic understanding of this machinery in yeast or metazoans. More recently, the discovery of small molecule inhibitors of CPSF function in Apicomplexa has stimulated interest in studying the specificities of this ancient eukaryotic machinery in these organisms. Although its function is conserved in Apicomplexa, the CPSF complex integrates a novel reader of the N6-methyladenosine (m6A). This feature, inherited from the plant kingdom, bridges m6A metabolism directly to 3'-end processing and by extension, to transcription termination. In this review, we will examine convergence and divergence of CPSF within the apicomplexan parasites and explore the potential of small molecule inhibition of this machinery within these organisms. This article is categorized under: RNA Processing > 3' End Processing RNA Processing > RNA Editing and Modification.

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来源期刊
CiteScore
14.80
自引率
4.10%
发文量
67
审稿时长
6-12 weeks
期刊介绍: WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
期刊最新文献
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