确定心外膜脂肪细胞形态预测因子的性别差异。

IF 3.5 4区 生物学 Q2 ENDOCRINOLOGY & METABOLISM Adipocyte Pub Date : 2022-12-01 DOI:10.1080/21623945.2022.2073854
Helen M M Waddell, Matthew K Moore, Morgan A Herbert-Olsen, Martin K Stiles, Rexson D Tse, Sean Coffey, Regis R Lamberts, Hamish M Aitken-Buck
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引用次数: 1

摘要

总体心外膜脂肪组织沉积的预测指标在男性和女性之间存在差异。心外膜脂肪细胞形态是否存在类似的性别差异目前尚不清楚。本研究旨在确定男性和女性心外膜脂肪细胞大小是否与不同的临床测量相关。从死后病例的心外膜、心旁和阑尾脂肪组织中测量脂肪细胞大小(N= 118,女性37)。心外膜、心包外和内脏脂肪体积通过计算机断层扫描测量(N= 70,22名女性)。进行相关分析和逐步线性回归来确定男性和女性脂肪细胞大小的预测因子。在所有仓库中,脂肪细胞大小的中位数在男性和女性之间没有差异。体重指数(BMI)和年龄是男性心外膜、心旁和阑尾脂肪细胞大小的独立预测指标,但对女性无效。仅在男性中,心外膜和阑尾脂肪细胞大小分别与心外膜和内脏脂肪体积相关。在女性中,心包旁脂肪细胞大小与心包外脂肪体积相关,而阑尾脂肪细胞大小仅与BMI相关。在单变量或多变量水平上,没有预测因子与女性心外膜脂肪细胞大小相关。综上所述,没有临床测量是女性心外膜脂肪细胞大小的有用替代品,而BMI、年龄和心外膜脂肪体积仅在男性中是独立的,尽管是微弱的预测因子。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Identifying sex differences in predictors of epicardial fat cell morphology.

Predictors of overall epicardial adipose tissue deposition have been found to vary between males and females. Whether similar sex differences exist in epicardial fat cell morphology is currently unknown. This study aimed to determine whether epicardial fat cell size is associated with different clinical measurements in males and females. Fat cell sizes were measured from epicardial, paracardial, and appendix adipose tissues of post-mortem cases (N= 118 total, 37 females). Epicardial, extra-pericardial, and visceral fat volumes were measured by computed tomography from a subset of cases (N= 70, 22 females). Correlation analyses and stepwise linear regression were performed to identify predictors of fat cell size in males and females. Median fat cell sizes in all depots did not differ between males and females. Body mass index (BMI) and age were independently predictive of epicardial, paracardial, and appendix fat cell sizes in males, but not in females. Epicardial and appendix fat cell sizes were associated with epicardial and visceral fat volumes, respectively, in males only. In females, paracardial fat cell size was associated with extra-pericardial fat volume, while appendix fat cell size was associated with BMI only. No predictors were associated with epicardial fat cell size in females at the univariable or multivariable levels. To conclude, no clinical measurements were useful surrogates of epicardial fat cell size in females, while BMI, age, and epicardial fat volume were independent, albeit weak, predictors in males only.

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来源期刊
Adipocyte
Adipocyte Medicine-Histology
CiteScore
6.50
自引率
3.00%
发文量
46
审稿时长
32 weeks
期刊介绍: Adipocyte recognizes that the adipose tissue is the largest endocrine organ in the body, and explores the link between dysfunctional adipose tissue and the growing number of chronic diseases including diabetes, hypertension, cardiovascular disease and cancer. Historically, the primary function of the adipose tissue was limited to energy storage and thermoregulation. However, a plethora of research over the past 3 decades has recognized the dynamic role of the adipose tissue and its contribution to a variety of physiological processes including reproduction, angiogenesis, apoptosis, inflammation, blood pressure, coagulation, fibrinolysis, immunity and general metabolic homeostasis. The field of Adipose Tissue research has grown tremendously, and Adipocyte is the first international peer-reviewed journal of its kind providing a multi-disciplinary forum for research focusing exclusively on all aspects of adipose tissue physiology and pathophysiology. Adipocyte accepts high-profile submissions in basic, translational and clinical research.
期刊最新文献
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