Rosie Morris , Douglas N. Martini , Valerie E. Kelly , Katrijn Smulders , Katrina Ramsey , Amie Hiller , Kathryn A. Chung , Shu-Ching Hu , Cyrus P. Zabetian , Kathleen L. Poston , Ignacio F. Mata , Karen L. Edwards , Jodi Lapidus , Brenna Cholerton , Thomas J. Montine , Joseph F. Quinn , Fay Horak
{"title":"老年人载脂蛋白Ɛ4等位基因携带者与帕金森病的步态和平衡","authors":"Rosie Morris , Douglas N. Martini , Valerie E. Kelly , Katrijn Smulders , Katrina Ramsey , Amie Hiller , Kathryn A. Chung , Shu-Ching Hu , Cyrus P. Zabetian , Kathleen L. Poston , Ignacio F. Mata , Karen L. Edwards , Jodi Lapidus , Brenna Cholerton , Thomas J. Montine , Joseph F. Quinn , Fay Horak","doi":"10.1016/j.prdoa.2023.100201","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Gait and balance impairments are among the most troublesome and heterogeneous in Parkinson’s disease (PD). This heterogeneity may, in part, reflect genetic variation. The apolipoprotein E (<em>APOE</em>) gene has three major allelic variants (ε2, ε3 and ε4). Previous work has demonstrated that older adult (OA) <em>APOE</em> ε4 carriers demonstrate gait deficits. This study compared gait and balance measures between <em>APOE</em> ε4 carriers and non-carriers in both OA and PD.</p></div><div><h3>Methods</h3><p>334 people with PD (81 <em>APOE</em> ε4 carriers and 253 non-carriers) and 144 OA (41 carriers and 103 non-carriers) were recruited. Gait and balance were assessed using body-worn inertial sensors. Two-way analyses of covariance (ANCOVA) compared gait and balance characteristics between <em>APOE</em> ε4 carriers and non-carriers in people with PD and OA, controlling for age, gender, and testing site.</p></div><div><h3>Results</h3><p>Gait and balance were worse in people with PD compared to OA. However, there were no differences between <em>APOE</em> ε4 carriers and non-carriers in either the OA or PD group. In addition, there were no significant group (OA/PD) by <em>APOE</em> ε4 status (carrier/non-carrier) interaction effects for any measures of gait or balance.</p></div><div><h3>Conclusions</h3><p>Although we found expected impairments in gait and balance in PD compared to OA, gait and balance characteristics did not differ between <em>APOE</em> ε4 carriers and non-carriers in either group. While <em>APOE</em> status did not impact gait and balance in this cross-sectional study, future work is needed to determine whether progression of gait and balance deficits is faster in PD <em>APOE</em> Ɛ4 carriers.</p></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f6/5e/main.PMC10209874.pdf","citationCount":"0","resultStr":"{\"title\":\"Gait and balance in apolipoprotein Ɛ4 allele carriers in older adults and Parkinson’s disease\",\"authors\":\"Rosie Morris , Douglas N. Martini , Valerie E. Kelly , Katrijn Smulders , Katrina Ramsey , Amie Hiller , Kathryn A. Chung , Shu-Ching Hu , Cyrus P. Zabetian , Kathleen L. Poston , Ignacio F. Mata , Karen L. Edwards , Jodi Lapidus , Brenna Cholerton , Thomas J. Montine , Joseph F. Quinn , Fay Horak\",\"doi\":\"10.1016/j.prdoa.2023.100201\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Gait and balance impairments are among the most troublesome and heterogeneous in Parkinson’s disease (PD). This heterogeneity may, in part, reflect genetic variation. The apolipoprotein E (<em>APOE</em>) gene has three major allelic variants (ε2, ε3 and ε4). Previous work has demonstrated that older adult (OA) <em>APOE</em> ε4 carriers demonstrate gait deficits. This study compared gait and balance measures between <em>APOE</em> ε4 carriers and non-carriers in both OA and PD.</p></div><div><h3>Methods</h3><p>334 people with PD (81 <em>APOE</em> ε4 carriers and 253 non-carriers) and 144 OA (41 carriers and 103 non-carriers) were recruited. Gait and balance were assessed using body-worn inertial sensors. Two-way analyses of covariance (ANCOVA) compared gait and balance characteristics between <em>APOE</em> ε4 carriers and non-carriers in people with PD and OA, controlling for age, gender, and testing site.</p></div><div><h3>Results</h3><p>Gait and balance were worse in people with PD compared to OA. However, there were no differences between <em>APOE</em> ε4 carriers and non-carriers in either the OA or PD group. In addition, there were no significant group (OA/PD) by <em>APOE</em> ε4 status (carrier/non-carrier) interaction effects for any measures of gait or balance.</p></div><div><h3>Conclusions</h3><p>Although we found expected impairments in gait and balance in PD compared to OA, gait and balance characteristics did not differ between <em>APOE</em> ε4 carriers and non-carriers in either group. While <em>APOE</em> status did not impact gait and balance in this cross-sectional study, future work is needed to determine whether progression of gait and balance deficits is faster in PD <em>APOE</em> Ɛ4 carriers.</p></div>\",\"PeriodicalId\":33691,\"journal\":{\"name\":\"Clinical Parkinsonism Related Disorders\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f6/5e/main.PMC10209874.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Parkinsonism Related Disorders\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2590112523000191\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Parkinsonism Related Disorders","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2590112523000191","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Gait and balance in apolipoprotein Ɛ4 allele carriers in older adults and Parkinson’s disease
Background
Gait and balance impairments are among the most troublesome and heterogeneous in Parkinson’s disease (PD). This heterogeneity may, in part, reflect genetic variation. The apolipoprotein E (APOE) gene has three major allelic variants (ε2, ε3 and ε4). Previous work has demonstrated that older adult (OA) APOE ε4 carriers demonstrate gait deficits. This study compared gait and balance measures between APOE ε4 carriers and non-carriers in both OA and PD.
Methods
334 people with PD (81 APOE ε4 carriers and 253 non-carriers) and 144 OA (41 carriers and 103 non-carriers) were recruited. Gait and balance were assessed using body-worn inertial sensors. Two-way analyses of covariance (ANCOVA) compared gait and balance characteristics between APOE ε4 carriers and non-carriers in people with PD and OA, controlling for age, gender, and testing site.
Results
Gait and balance were worse in people with PD compared to OA. However, there were no differences between APOE ε4 carriers and non-carriers in either the OA or PD group. In addition, there were no significant group (OA/PD) by APOE ε4 status (carrier/non-carrier) interaction effects for any measures of gait or balance.
Conclusions
Although we found expected impairments in gait and balance in PD compared to OA, gait and balance characteristics did not differ between APOE ε4 carriers and non-carriers in either group. While APOE status did not impact gait and balance in this cross-sectional study, future work is needed to determine whether progression of gait and balance deficits is faster in PD APOE Ɛ4 carriers.