真核剪接机器在植物病毒的战场上。

IF 6.4 2区 生物学 Q1 CELL BIOLOGY Wiley Interdisciplinary Reviews: RNA Pub Date : 2023-09-01 Epub Date: 2023-05-17 DOI:10.1002/wrna.1793
Chang-Feng Su, Debatosh Das, Mehtab Muhammad Aslam, Ji-Qin Xie, Xiang-Yang Li, Mo-Xian Chen
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引用次数: 1

摘要

植物病毒感染主要由影响生态群落的植物病毒寄生引起。有些病毒具有高度的病原体特异性,只能感染特定的植物,而有些病毒则会造成广泛的危害,如烟草花叶病毒(TMV)和黄瓜花叶病毒(CMV)。病毒感染宿主后,会产生一系列有害影响,包括破坏宿主细胞膜受体、改变细胞膜成分、细胞融合以及在细胞表面产生新抗原。因此,宿主和病毒之间产生了竞争。病毒开始控制宿主细胞的关键细胞功能,并最终影响目标宿主植物的命运。在这些关键的细胞过程中,选择性剪接(AS)是RNA成熟中一个重要的转录后调节过程,它放大宿主蛋白质的多样性,并操纵转录物的丰度以应对植物病原体。AS广泛存在于几乎所有人类基因中,对调节动物与病毒的相互作用至关重要。特别是,动物病毒可以劫持宿主的剪接机制,重新组织其隔间进行繁殖。众所周知,AS的变化会导致人类疾病,据报道,各种AS事件可以调节组织特异性、发育、肿瘤增殖和多功能。然而,人们对植物病毒相互作用的机制知之甚少。在这里,我们总结了目前对病毒与植物宿主相互作用的理解,并与人类进行了比较,分析了目前使用的和公认的治疗植物病毒感染的候选农用化学品,最后讨论了未来潜在的研究热点。本文分类如下:RNA加工>剪接机制RNA加工>拼接调控/选择性剪接。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Eukaryotic splicing machinery in the plant-virus battleground.

Plant virual infections are mainly caused by plant-virus parasitism which affects ecological communities. Some viruses are highly pathogen specific that can infect only specific plants, while some can cause widespread harm, such as tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV). After a virus infects the host, undergoes a series of harmful effects, including the destruction of host cell membrane receptors, changes in cell membrane components, cell fusion, and the production of neoantigens on the cell surface. Therefore, competition between the host and the virus arises. The virus starts gaining control of critical cellular functions of the host cells and ultimately affects the fate of the targeted host plants. Among these critical cellular processes, alternative splicing (AS) is an essential posttranscriptional regulation process in RNA maturation, which amplify host protein diversity and manipulates transcript abundance in response to plant pathogens. AS is widespread in nearly all human genes and critical in regulating animal-virus interactions. In particular, an animal virus can hijack the host splicing machinery to re-organize its compartments for propagation. Changes in AS are known to cause human disease, and various AS events have been reported to regulate tissue specificity, development, tumour proliferation, and multi-functionality. However, the mechanisms underlying plant-virus interactions are poorly understood. Here, we summarize the current understanding of how viruses interact with their plant hosts compared with humans, analyze currently used and putative candidate agrochemicals to treat plant-viral infections, and finally discussed the potential research hotspots in the future. This article is categorized under: RNA Processing > Splicing Mechanisms RNA Processing > Splicing Regulation/Alternative Splicing.

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来源期刊
CiteScore
14.80
自引率
4.10%
发文量
67
审稿时长
6-12 weeks
期刊介绍: WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
期刊最新文献
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