Duygu Tugrul Ersak, Hakkı Şerbetçi, Bergen Laleli Koç, Özgür Kara, Şeyma Bütün Türk, Gülsüm Kadıoğlu Şimşek, Fuat Emre Canpolat, Özlem Moraloğlu Tekin, Dilek Şahin
{"title":"胎盘病理学及其在早产儿中的重要性。","authors":"Duygu Tugrul Ersak, Hakkı Şerbetçi, Bergen Laleli Koç, Özgür Kara, Şeyma Bütün Türk, Gülsüm Kadıoğlu Şimşek, Fuat Emre Canpolat, Özlem Moraloğlu Tekin, Dilek Şahin","doi":"10.1080/15513815.2023.2223297","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>We evaluated what placental pathologies were associated with adverse preterm births.</p><p><strong>Materials and methods: </strong>Placental findings, classified according to the Amsterdam criteria, were correlated with infant outcomes. The fetal vascular lesions, inflammatory responses other than histological chorioamnionitis (HCA), and placentas with combined maternal vascular malperfusion (MVM) and HCA were excluded.</p><p><strong>Results: </strong>A total of 772 placentas were evaluated. MVM was present in 394 placentas, HCA in 378. Early neonatal sepsis, retinopathy of prematurity, necrotizing enterocolitis, and neonatal death occurred more often in the MVM-only group than HCA-only group. The frequency of bronchopulmonary dysplasia (BPD) was 38.6% in the HCA-only group, and it was 20.3% in the MVM-only group (<i>p</i> < 0.001). HCA was the most important independent risk factor for BPD (OR 3.877, 95% CI 2.831-5.312).</p><p><strong>Conclusion: </strong>Inflammation in the placenta influences fetal and neonatal outcomes. HCA is an independent risk factor for BPD.</p>","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":"42 5","pages":"746-752"},"PeriodicalIF":0.7000,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Placental Pathology and Its Importance in Preterm Infants.\",\"authors\":\"Duygu Tugrul Ersak, Hakkı Şerbetçi, Bergen Laleli Koç, Özgür Kara, Şeyma Bütün Türk, Gülsüm Kadıoğlu Şimşek, Fuat Emre Canpolat, Özlem Moraloğlu Tekin, Dilek Şahin\",\"doi\":\"10.1080/15513815.2023.2223297\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>We evaluated what placental pathologies were associated with adverse preterm births.</p><p><strong>Materials and methods: </strong>Placental findings, classified according to the Amsterdam criteria, were correlated with infant outcomes. The fetal vascular lesions, inflammatory responses other than histological chorioamnionitis (HCA), and placentas with combined maternal vascular malperfusion (MVM) and HCA were excluded.</p><p><strong>Results: </strong>A total of 772 placentas were evaluated. MVM was present in 394 placentas, HCA in 378. Early neonatal sepsis, retinopathy of prematurity, necrotizing enterocolitis, and neonatal death occurred more often in the MVM-only group than HCA-only group. The frequency of bronchopulmonary dysplasia (BPD) was 38.6% in the HCA-only group, and it was 20.3% in the MVM-only group (<i>p</i> < 0.001). HCA was the most important independent risk factor for BPD (OR 3.877, 95% CI 2.831-5.312).</p><p><strong>Conclusion: </strong>Inflammation in the placenta influences fetal and neonatal outcomes. HCA is an independent risk factor for BPD.</p>\",\"PeriodicalId\":50452,\"journal\":{\"name\":\"Fetal and Pediatric Pathology\",\"volume\":\"42 5\",\"pages\":\"746-752\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2023-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Fetal and Pediatric Pathology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/15513815.2023.2223297\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/6/21 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"PATHOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fetal and Pediatric Pathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/15513815.2023.2223297","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/6/21 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"PATHOLOGY","Score":null,"Total":0}
Placental Pathology and Its Importance in Preterm Infants.
Objective: We evaluated what placental pathologies were associated with adverse preterm births.
Materials and methods: Placental findings, classified according to the Amsterdam criteria, were correlated with infant outcomes. The fetal vascular lesions, inflammatory responses other than histological chorioamnionitis (HCA), and placentas with combined maternal vascular malperfusion (MVM) and HCA were excluded.
Results: A total of 772 placentas were evaluated. MVM was present in 394 placentas, HCA in 378. Early neonatal sepsis, retinopathy of prematurity, necrotizing enterocolitis, and neonatal death occurred more often in the MVM-only group than HCA-only group. The frequency of bronchopulmonary dysplasia (BPD) was 38.6% in the HCA-only group, and it was 20.3% in the MVM-only group (p < 0.001). HCA was the most important independent risk factor for BPD (OR 3.877, 95% CI 2.831-5.312).
Conclusion: Inflammation in the placenta influences fetal and neonatal outcomes. HCA is an independent risk factor for BPD.
期刊介绍：
Fetal and Pediatric Pathology is an established bimonthly international journal that publishes data on diseases of the developing embryo, newborns, children, and adolescents. The journal publishes original and review articles and reportable case reports.
The expanded scope of the journal encompasses molecular basis of genetic disorders; molecular basis of diseases that lead to implantation failures; molecular basis of abnormal placentation; placentology and molecular basis of habitual abortion; intrauterine development and molecular basis of embryonic death; pathogenisis and etiologic factors involved in sudden infant death syndrome; the underlying molecular basis, and pathogenesis of diseases that lead to morbidity and mortality in newborns; prenatal, perinatal, and pediatric diseases and molecular basis of diseases of childhood including solid tumors and tumors of the hematopoietic system; and experimental and molecular pathology.
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