筛查妊娠糖尿病和妊娠结局:来自塔吉克斯坦一项多中心研究的结果

IF 1.6 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Experimental and Clinical Endocrinology & Diabetes Pub Date : 2022-12-01 DOI:10.1055/a-1869-4159
Dilnoza Pirmatova, Munavvara Dodkhoeva, Uwe Hasbargen, Andreas W Flemmer, Zulfiya Abdusamatzoda, Khursheda Saburova, Nasiba Salieva, Surayyo Radzhabova, Klaus G Parhofer
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引用次数: 1

摘要

妊娠期糖尿病的患病率与2型糖尿病的患病率相似,并与不良妊娠结局相关。然而,世界上许多地方都没有这些数据。我们评估了塔吉克斯坦妊娠期糖尿病的患病率和妊娠结局。该队列研究从塔吉克斯坦两个城市的8个地点连续招募2438名有代表性的孕妇,在妊娠24-28周进行口服葡萄糖耐量试验(75 g,禁食,1小时,2小时)。已知患有糖尿病和双胎妊娠的妇女被排除在外。研究葡萄糖耐量试验结果与妊娠结局之间的关系。根据世界卫生组织2013年的阈值,32.4%的妇女有资格患有妊娠糖尿病,绝大多数(29.7%)是基于空腹血糖水平升高(5.1-5.6 mmol/L),而只有2.8%的1或2小时血糖升高或达到一个以上的阈值。仅空腹血糖升高(妊娠空腹血糖受损)的妇女没有不良妊娠结局的证据,而1小时和/或2小时血糖升高(妊娠糖耐量受损)的妇女有更多的妊娠并发症(尿路感染1.8比8.8% p
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Screening for Gestational Diabetes Mellitus and Pregnancy Outcomes: Results from a Multicentric Study in Tajikistan.

The prevalence of gestational diabetes parallels the prevalence of type 2 diabetes mellitus and is associated with adverse pregnancy outcomes. However, these data are not available for many parts of the world. We assessed the prevalence of gestational diabetes and pregnancy outcomes in Tajikistan. This cohort study included 2438 consecutively recruited representative pregnant women from 8 locations in two cities in Tajikistan, in whom an oral glucose tolerance test (75 g, fasting, 1 h, 2 h) was performed during gestational weeks 24-28. Women with known diabetes and twin pregnancies were excluded. Associations between glucose tolerance test results and pregnancy outcomes were examined. According to the WHO 2013 thresholds, 32.4% of women qualified as having gestational diabetes, the vast majority (29.7%) based on an elevated fasting glucose level (5.1-5.6 mmol/L), while only 2.8% had elevated 1- or 2-hour values or met more than one threshold. Women with only elevated fasting glucose (impaired gestational fasting glycemia) had no evidence of adverse pregnancy outcomes, while those with elevated 1- and/or 2-hour values (impaired gestational glucose tolerance) had more pregnancy complications (infection of urinary tract 1.8 vs. 8.8% p<0.001; preeclampsia 0.7 vs. 10.3% p<0.001) and emergency cesarean sections (4.4 vs. 13.2% p=0.002). Neonates from pregnancies with impaired gestational glucose tolerance had lower APGARs, lower birth weights, lower 30 min glucose levels, and a lower probability of being discharged alive (all p<0.05). In conclusion, the formal prevalence of gestational diabetes is high in Tajikistan; however, this does not translate into adverse pregnancy outcomes for women with impaired gestational fasting glycemia.

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来源期刊
CiteScore
4.10
自引率
5.60%
发文量
72
审稿时长
3 months
期刊介绍: Publishing outstanding articles from all fields of endocrinology and diabetology, from molecular biology to clinical research, this journal is a brilliant resource. Since being published in English in 1983, the popularity of this journal has grown steadily, reflecting the importance of this publication within its field. Original contributions and short communications appear in each issue along with reviews addressing current topics. In addition, supplementary issues are published each year presenting abstracts or proceedings of national and international scientific meetings. The journal was initially published in German and is still the oldest endocrinological periodical in the German-language market!
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