基于壳聚糖/羟丙基甲基纤维素和聚乙烯吡咯烷酮/羟丙基甲纤维素聚合物混合物的用于庆大霉素给药的透皮贴剂。

IF 1.4 Q3 Pharmacology, Toxicology and Pharmaceutics Journal of Advanced Pharmaceutical Technology & Research Pub Date : 2023-07-01 Epub Date: 2023-07-28 DOI:10.4103/japtr.japtr_130_23
Saif Aldeen Jaber
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引用次数: 0

摘要

形成生物膜的细菌已经向世界发出了细菌耐药性出现的警报。庆大霉素是一种氨基糖苷类广谱抗生素,用于对抗微生物感染。透皮给药方法是用于降低药物毒性和避免首次通过代谢的主要系统。在棕榈酸作为渗透促进剂的存在下,使用羟丙基甲基纤维素(HPMC)、聚乙烯吡咯烷酮(PVP)和壳聚糖以透皮聚合物配方配制庆大霉素。在本研究中,庆大霉素在含有(HPMC/PVP)和(HPMC/壳聚糖)的不同聚合物配方中成功地进行了缓释行为,最大药物释放量为
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Transdermal patches based on chitosan/hydroxypropyl methylcellulose and polyvinylpyrrolidone/hydroxypropyl methylcellulose polymer blends for gentamycin administration.

Biofilm-forming bacteria have sent alarms to the world about the emerging of bacterial resistance. Gentamycin is an aminoglycoside broad-spectrum antibiotic used against microbial infections. The transdermal drug delivery method is a major system used to reduce drug toxicity and avoid first-pass metabolism. Gentamycin was formulated in a transdermal polymeric formula using hydroxypropyl methylcellulose (HPMC), polyvinylpyrrolidone (PVP), and Chitosan in the presence of palmitic acid as a permeation enhancer. In this research, gentamycin extended drug release behavior was successfully done in different polymeric formulas containing (HPMC/PVP) and (HPMC/Chitosan), with a maximum drug release of <70%. In addition, drug diffusion was found to be dependent on the rate of drug release. The controlled release formulas selected for antimicrobial assay show that HPMC/Chitosan formulas have successfully inhibited microbial and biofilm growth by 90%. In conclusion, gentamycin can be formulated in a transdermal polymeric film to target skin infection, reduce drug side effects and avoid drug first-pass metabolism.

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来源期刊
CiteScore
2.00
自引率
7.10%
发文量
44
审稿时长
20 weeks
期刊介绍: Journal of Advanced Pharmaceutical Technology & Research (JAPTR) is an Official Publication of Society of Pharmaceutical Education & Research™. It is an international journal published Quarterly. Journal of Advanced Pharmaceutical Technology & Research (JAPTR) is available in online and print version. It is a peer reviewed journal aiming to communicate high quality original research work, reviews, short communications, case report, Ethics Forum, Education Forum and Letter to editor that contribute significantly to further the scientific knowledge related to the field of Pharmacy i.e. Pharmaceutics, Pharmacology, Pharmacognosy, Pharmaceutical Chemistry. Articles with timely interest and newer research concepts will be given more preference.
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