液体活检在低级别胶质瘤:一个系统评价和一个临床效用评分的建议。

IF 3.6 4区 医学 Q3 CELL BIOLOGY Cellular and Molecular Neurobiology Pub Date : 2023-11-01 Epub Date: 2023-09-13 DOI:10.1007/s10571-023-01406-9
Luca Zanin, Alexandra Sachkova, Pier Paolo Panciani, Veit Rohde, Marco Maria Fontanella, Bawarjan Schatlo
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引用次数: 0

摘要

液体活检对低级别胶质瘤(LGG)的研究一直不像对其他恶性脑肿瘤那样引人注目。可靠的血清标志物对诊断、随访和治疗具有重要意义。我们提出了LGG生物标志物的临床效用评分(CUS),反映了它们的临床用途。我们进行了PRISMA审查。我们检查了每个生物标志物,并按CUS和证据水平(LOE)对它们进行分类。我们确定了四类生物标志物:(1)循环蛋白-(a)玻璃体连接蛋白区分LGG和HGG (Sn:98%, Sp:91%, CUS:3, LOE:III), (b) CTLA-4区分LGG和HGG(临界值:220.43 pg/ml, Sn: 82%, Sp: 78%, CUS:3, LOE:III), (c)术前TGF b1预测星形细胞瘤(临界值:2.52 ng/ml, Sn: 94.9%, Sp: 100%, CUS:3, LOE:VI)。(2).微rna (miR)-(a) miR-16区分WHO IV组和WHO II组和III组(AUC = 0.98, CUS:3, LOE: III), (b) miR-454-3p在HGG中高于LGG (p = 0.013, CUS:3, LOE: III), (c) miR-210表达与WHO分级相关(Sn: 83.2%, Sp: 94.3%, CUS:3, LOE: III)。(3).循环DNA-(a)结合COLD和数字PCR检测血浆中IDH1R132H突变(Sn: 60%, Sp: 100%, CUS:3, LOE: III)。外泌体-(a)血清SDC1水平可以区分GBM和LGG (Sn: 71%, Sp: 91%, CUS: 2C, LOE: VI)。我们的研究表明,miRs似乎具有最高的临床应用价值。所评估的研究的LOE通常较低。可以考虑将不同的生物标志物与传统诊断相结合。我们确定了由LGG产生的四类主要生物标志物。我们检查了每个生物标志物,根据临床效用评分(CUS)和证据水平(LOE)对它们进行分类。微rna (miRs)似乎具有最高的CUS和LOE。
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Liquid Biopsy in Low-Grade Glioma: A Systematic Review and a Proposal for a Clinical Utility Score.

Liquid biopsy research on Low-Grade gliomas (LGG) has remained less conspicuous than that on other malignant brain tumors. Reliable serum markers would be precious for diagnosis, follow- up and treatment. We propose a clinical utility score (CUS) for biomarkers in LGG that mirrors their clinical usefulness. We conducted a PRISMA review. We examined each biomarker classifying them by CUS and Level of Evidence (LOE). We identified four classes of biomarkers: (1). Circulating protein-(a) vitronectin discriminates LGG from HGG (Sn:98%, Sp:91%, CUS: 3, LOE: III), (b) CTLA-4 discriminates LGG from HGG, (cutoff: 220.43 pg/ml, Sn: 82%, Sp: 78%, CUS:3, LOE:III), (c) pre-operative TGF b1 predict astrocytoma (cutoff: 2.52 ng/ml, Sn: 94.9%, Sp: 100%, CUS:3, LOE:VI). (2). micro-RNA (miR)-(a) miR-16 discriminates between WHO IV and WHO II and III groups (AUC = 0.98, CUS:3, LOE: III), (b) miR-454-3p is higher in HGG than in LGG (p = 0.013, CUS:3, LOE: III), (c) miR-210 expression is related to WHO grades (Sn 83.2%, Sp 94.3%, CUS: 3, LOE: III). (3). Circulating DNA-(a) IDH1R132H mutation detected in plasma by combined COLD and digital PCR (Sn: 60%, Sp: 100%, CUS: 3, LOE: III). 4. Exosomes-(a) SDC1 serum levels could discriminate GBM from LGG (Sn: 71%, Sp: 91%, CUS: 2C, LOE: VI). Our investigation showed that miRs appear to have the highest clinical utility. The LOE of the studies assessed is generally low. A combined approach between different biomarkers and traditional diagnostics may be considered. We identified four main classes of biomarkers produced by LGG. We examined each biomarker, classifying them by clinical utility score (CUS) and level of evidence (LOE). Micro-RNA (miRs) appears to have the highest CUS and LOE.

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来源期刊
CiteScore
7.70
自引率
0.00%
发文量
137
审稿时长
4-8 weeks
期刊介绍: Cellular and Molecular Neurobiology publishes original research concerned with the analysis of neuronal and brain function at the cellular and subcellular levels. The journal offers timely, peer-reviewed articles that describe anatomic, genetic, physiologic, pharmacologic, and biochemical approaches to the study of neuronal function and the analysis of elementary mechanisms. Studies are presented on isolated mammalian tissues and intact animals, with investigations aimed at the molecular mechanisms or neuronal responses at the level of single cells. Cellular and Molecular Neurobiology also presents studies of the effects of neurons on other organ systems, such as analysis of the electrical or biochemical response to neurotransmitters or neurohormones on smooth muscle or gland cells.
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