J S Talboom, M D De Both, M A Naymik, A M Schmidt, C R Lewis, W M Jepsen, A K Håberg, T Rundek, B E Levin, S Hoscheidt, Y Bolla, R D Brinton, N J Schork, M Hay, C A Barnes, E Glisky, L Ryan, M J Huentelman
{"title":"两个独立的大型队列揭示了与年龄相关的视觉反应时间表现变化的潜在修饰因素。","authors":"J S Talboom, M D De Both, M A Naymik, A M Schmidt, C R Lewis, W M Jepsen, A K Håberg, T Rundek, B E Levin, S Hoscheidt, Y Bolla, R D Brinton, N J Schork, M Hay, C A Barnes, E Glisky, L Ryan, M J Huentelman","doi":"10.1038/s41514-021-00067-6","DOIUrl":null,"url":null,"abstract":"<p><p>To identify potential factors influencing age-related cognitive decline and disease, we created MindCrowd. MindCrowd is a cross-sectional web-based assessment of simple visual (sv) reaction time (RT) and paired-associate learning (PAL). svRT and PAL results were combined with 22 survey questions. Analysis of svRT revealed education and stroke as potential modifiers of changes in processing speed and memory from younger to older ages (n<sub>total</sub> = 75,666, n<sub>women</sub> = 47,700, n<sub>men</sub> = 27,966; ages 18-85 years old, mean (M)<sub>Age</sub> = 46.54, standard deviation (SD)<sub>Age</sub> = 18.40). To complement this work, we evaluated complex visual recognition reaction time (cvrRT) in the UK Biobank (n<sub>total</sub> = 158,249 n<sub>women</sub> = 89,333 n<sub>men</sub> = 68,916; ages 40-70 years old, M<sub>Age</sub> = 55.81, SD<sub>Age</sub> = 7.72). Similarities between the UK Biobank and MindCrowd were assessed using a subset of MindCrowd (UKBb MindCrowd) selected to mirror the UK Biobank demographics (n<sub>total</sub> = 39,795, n<sub>women</sub> = 29,640, n<sub>men</sub> = 10,155; ages 40-70 years old, M<sub>Age</sub> = 56.59, SD<sub>Age</sub> = 8.16). An identical linear model (LM) was used to assess both cohorts. Analyses revealed similarities between MindCrowd and the UK Biobank across most results. Divergent findings from the UK Biobank included (1) a first-degree family history of Alzheimer's disease (FHAD) was associated with longer cvrRT. (2) Men with the least education were associated with longer cvrRTs comparable to women across all educational attainment levels. Divergent findings from UKBb MindCrowd included more education being associated with shorter svRTs and a history of smoking with longer svRTs from younger to older ages.</p>","PeriodicalId":19334,"journal":{"name":"NPJ Aging and Mechanisms of Disease","volume":null,"pages":null},"PeriodicalIF":5.4000,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/s41514-021-00067-6","citationCount":"9","resultStr":"{\"title\":\"Two separate, large cohorts reveal potential modifiers of age-associated variation in visual reaction time performance.\",\"authors\":\"J S Talboom, M D De Both, M A Naymik, A M Schmidt, C R Lewis, W M Jepsen, A K Håberg, T Rundek, B E Levin, S Hoscheidt, Y Bolla, R D Brinton, N J Schork, M Hay, C A Barnes, E Glisky, L Ryan, M J Huentelman\",\"doi\":\"10.1038/s41514-021-00067-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>To identify potential factors influencing age-related cognitive decline and disease, we created MindCrowd. MindCrowd is a cross-sectional web-based assessment of simple visual (sv) reaction time (RT) and paired-associate learning (PAL). svRT and PAL results were combined with 22 survey questions. Analysis of svRT revealed education and stroke as potential modifiers of changes in processing speed and memory from younger to older ages (n<sub>total</sub> = 75,666, n<sub>women</sub> = 47,700, n<sub>men</sub> = 27,966; ages 18-85 years old, mean (M)<sub>Age</sub> = 46.54, standard deviation (SD)<sub>Age</sub> = 18.40). To complement this work, we evaluated complex visual recognition reaction time (cvrRT) in the UK Biobank (n<sub>total</sub> = 158,249 n<sub>women</sub> = 89,333 n<sub>men</sub> = 68,916; ages 40-70 years old, M<sub>Age</sub> = 55.81, SD<sub>Age</sub> = 7.72). Similarities between the UK Biobank and MindCrowd were assessed using a subset of MindCrowd (UKBb MindCrowd) selected to mirror the UK Biobank demographics (n<sub>total</sub> = 39,795, n<sub>women</sub> = 29,640, n<sub>men</sub> = 10,155; ages 40-70 years old, M<sub>Age</sub> = 56.59, SD<sub>Age</sub> = 8.16). An identical linear model (LM) was used to assess both cohorts. Analyses revealed similarities between MindCrowd and the UK Biobank across most results. Divergent findings from the UK Biobank included (1) a first-degree family history of Alzheimer's disease (FHAD) was associated with longer cvrRT. (2) Men with the least education were associated with longer cvrRTs comparable to women across all educational attainment levels. Divergent findings from UKBb MindCrowd included more education being associated with shorter svRTs and a history of smoking with longer svRTs from younger to older ages.</p>\",\"PeriodicalId\":19334,\"journal\":{\"name\":\"NPJ Aging and Mechanisms of Disease\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.4000,\"publicationDate\":\"2021-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1038/s41514-021-00067-6\",\"citationCount\":\"9\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"NPJ Aging and Mechanisms of Disease\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1038/s41514-021-00067-6\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"NPJ Aging and Mechanisms of Disease","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s41514-021-00067-6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
Two separate, large cohorts reveal potential modifiers of age-associated variation in visual reaction time performance.
To identify potential factors influencing age-related cognitive decline and disease, we created MindCrowd. MindCrowd is a cross-sectional web-based assessment of simple visual (sv) reaction time (RT) and paired-associate learning (PAL). svRT and PAL results were combined with 22 survey questions. Analysis of svRT revealed education and stroke as potential modifiers of changes in processing speed and memory from younger to older ages (ntotal = 75,666, nwomen = 47,700, nmen = 27,966; ages 18-85 years old, mean (M)Age = 46.54, standard deviation (SD)Age = 18.40). To complement this work, we evaluated complex visual recognition reaction time (cvrRT) in the UK Biobank (ntotal = 158,249 nwomen = 89,333 nmen = 68,916; ages 40-70 years old, MAge = 55.81, SDAge = 7.72). Similarities between the UK Biobank and MindCrowd were assessed using a subset of MindCrowd (UKBb MindCrowd) selected to mirror the UK Biobank demographics (ntotal = 39,795, nwomen = 29,640, nmen = 10,155; ages 40-70 years old, MAge = 56.59, SDAge = 8.16). An identical linear model (LM) was used to assess both cohorts. Analyses revealed similarities between MindCrowd and the UK Biobank across most results. Divergent findings from the UK Biobank included (1) a first-degree family history of Alzheimer's disease (FHAD) was associated with longer cvrRT. (2) Men with the least education were associated with longer cvrRTs comparable to women across all educational attainment levels. Divergent findings from UKBb MindCrowd included more education being associated with shorter svRTs and a history of smoking with longer svRTs from younger to older ages.
期刊介绍:
npj Aging and Mechanisms of Disease is an online open access journal that provides a forum for the world’s most important research in the fields of aging and aging-related disease. The journal publishes papers from all relevant disciplines, encouraging those that shed light on the mechanisms behind aging and the associated diseases. The journal’s scope includes, but is not restricted to, the following areas (not listed in order of preference): • cellular and molecular mechanisms of aging and aging-related diseases • interventions to affect the process of aging and longevity • homeostatic regulation and aging • age-associated complications • translational research into prevention and treatment of aging-related diseases • mechanistic bases for epidemiological aspects of aging-related disease.