两个独立的大型队列揭示了与年龄相关的视觉反应时间表现变化的潜在修饰因素。

IF 5.4 Q1 GERIATRICS & GERONTOLOGY NPJ Aging and Mechanisms of Disease Pub Date : 2021-07-01 DOI:10.1038/s41514-021-00067-6
J S Talboom, M D De Both, M A Naymik, A M Schmidt, C R Lewis, W M Jepsen, A K Håberg, T Rundek, B E Levin, S Hoscheidt, Y Bolla, R D Brinton, N J Schork, M Hay, C A Barnes, E Glisky, L Ryan, M J Huentelman
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引用次数: 9

摘要

为了确定影响与年龄相关的认知能力下降和疾病的潜在因素,我们创建了MindCrowd。MindCrowd是一个基于网络的简单视觉(sv)反应时间(RT)和配对联想学习(PAL)的横向评估。svRT和PAL结果与22个调查问题相结合。svRT分析显示,受教育程度和脑卒中是处理速度和记忆从年轻到老年变化的潜在调节因素(ntotal = 75,666, nwomen = 47,700, nmen = 27,966;年龄18-85岁,平均(M)年龄= 46.54,标准差(SD)年龄= 18.40。为了补充这项工作,我们评估了英国生物银行的复杂视觉识别反应时间(cvrRT) (ntotal = 158,249,女性= 89,333,男性= 68,916;年龄40 ~ 70岁,MAge = 55.81, SDAge = 7.72)。UK Biobank和MindCrowd之间的相似性是使用MindCrowd (UKBb MindCrowd)的一个子集来评估的,该子集被选择来反映UK Biobank的人口统计数据(ntotal = 39,795, nwomen = 29,640, nmen = 10,155;年龄40 ~ 70岁,MAge = 56.59, SDAge = 8.16)。采用相同的线性模型(LM)对两个队列进行评估。分析显示,MindCrowd和UK Biobank在大多数结果上都有相似之处。来自英国生物银行的不同发现包括:(1)阿尔茨海默病(FHAD)的一级家族史与较长的cvrRT相关。(2)在所有受教育程度中,受教育程度最低的男性与女性相比,其平均寿命更长。来自UKBb MindCrowd的不同发现包括,受教育程度越高,svrt越短,而吸烟史越长,从年轻到老年的svrt越长。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Two separate, large cohorts reveal potential modifiers of age-associated variation in visual reaction time performance.

To identify potential factors influencing age-related cognitive decline and disease, we created MindCrowd. MindCrowd is a cross-sectional web-based assessment of simple visual (sv) reaction time (RT) and paired-associate learning (PAL). svRT and PAL results were combined with 22 survey questions. Analysis of svRT revealed education and stroke as potential modifiers of changes in processing speed and memory from younger to older ages (ntotal = 75,666, nwomen = 47,700, nmen = 27,966; ages 18-85 years old, mean (M)Age = 46.54, standard deviation (SD)Age = 18.40). To complement this work, we evaluated complex visual recognition reaction time (cvrRT) in the UK Biobank (ntotal = 158,249 nwomen = 89,333 nmen = 68,916; ages 40-70 years old, MAge = 55.81, SDAge = 7.72). Similarities between the UK Biobank and MindCrowd were assessed using a subset of MindCrowd (UKBb MindCrowd) selected to mirror the UK Biobank demographics (ntotal = 39,795, nwomen = 29,640, nmen = 10,155; ages 40-70 years old, MAge = 56.59, SDAge = 8.16). An identical linear model (LM) was used to assess both cohorts. Analyses revealed similarities between MindCrowd and the UK Biobank across most results. Divergent findings from the UK Biobank included (1) a first-degree family history of Alzheimer's disease (FHAD) was associated with longer cvrRT. (2) Men with the least education were associated with longer cvrRTs comparable to women across all educational attainment levels. Divergent findings from UKBb MindCrowd included more education being associated with shorter svRTs and a history of smoking with longer svRTs from younger to older ages.

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NPJ Aging and Mechanisms of Disease
NPJ Aging and Mechanisms of Disease Medicine-Geriatrics and Gerontology
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期刊介绍: npj Aging and Mechanisms of Disease is an online open access journal that provides a forum for the world’s most important research in the fields of aging and aging-related disease. The journal publishes papers from all relevant disciplines, encouraging those that shed light on the mechanisms behind aging and the associated diseases. The journal’s scope includes, but is not restricted to, the following areas (not listed in order of preference): • cellular and molecular mechanisms of aging and aging-related diseases • interventions to affect the process of aging and longevity • homeostatic regulation and aging • age-associated complications • translational research into prevention and treatment of aging-related diseases • mechanistic bases for epidemiological aspects of aging-related disease.
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