ir包覆pd - pt纳米枝作为纳米酶增强过氧化物酶样和抗菌活性。

IF 4.7 3区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Bioinorganic Chemistry and Applications Pub Date : 2023-01-01 DOI:10.1155/2023/1689455

Jingfang Song, Jian He, Lin Yang, Weiguo Wang, Qinqin Bai, Wei Feng, Ranhui Li

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引用次数: 2

摘要

为了抑制细菌的生长，合成了具有过氧化物酶样活性的DA-PPI纳米酶。通过在Pd-Pt树枝状结构表面沉积高亲和力元素铱(Ir)获得DA-PPI纳米酶。利用扫描电镜(SEM)、透射电镜(TEM)和XPS表征了DA-PPI纳米酶的形态和组成。动力学结果表明，DA-PPI纳米酶比Pd-Pt树状结构具有更高的过氧化物酶样活性。用PL、ESR和DFT来解释高过氧化物酶活性。作为概念证明，DA-PPI纳米酶由于具有高过氧化物酶样活性，可以有效抑制大肠杆菌(G-)和金黄色葡萄球菌(G+)。该研究为高活性纳米酶的设计及其在抗菌领域的应用提供了新的思路。

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Enhanced Peroxidase-Like and Antibacterial Activity of Ir-CoatedPd-Pt Nanodendrites as Nanozyme.

To inhibit the growth of bacteria, the DA-PPI nanozyme with enhanced peroxidase-like activity was synthesized. The DA-PPI nanozyme was obtained by depositing high-affinity element iridium (Ir) on the surface of Pd-Pt dendritic structures. The morphology and composition of DA-PPI nanozyme were characterized using SEM, TEM, and XPS. The kinetic results showed that the DA-PPI nanozyme possessed a higher peroxidase-like activity than that of Pd-Pt dendritic structures. The PL, ESR, and DFT were employed to explain the high peroxidase activity. As a proof of concept, the DA-PPI nanozyme could effectively inhibit E. coli (G^-) and S. aureus (G⁺) due to its high peroxidase-like activity. The study provides a new idea for the design of high active nanozymes and their application in the field of antibacterial.

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来源期刊

Bioinorganic Chemistry and Applications 化学-生化与分子生物学

CiteScore

7.00

自引率

5.30%

发文量

105

审稿时长

>12 weeks

期刊介绍： Bioinorganic Chemistry and Applications is primarily devoted to original research papers, but also publishes review articles, editorials, and letter to the editor in the general field of bioinorganic chemistry and its applications. Its scope includes all aspects of bioinorganic chemistry, including bioorganometallic chemistry and applied bioinorganic chemistry. The journal welcomes papers relating to metalloenzymes and model compounds, metal-based drugs, biomaterials, biocatalysis and bioelectronics, metals in biology and medicine, metals toxicology and metals in the environment, metal interactions with biomolecules and spectroscopic applications.