静脉注射蔗糖铁与羧麦芽糖铁治疗妊娠和产后缺铁性贫血的比较研究

Nitin Kulkarni, P. Pawar, R. Bansal
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摘要

目的:本研究旨在探讨三羧基麦芽糖铁治疗缺铁性贫血比蔗糖铁治疗的优势。方法:于2017年1月至2017年12月在ACPM医学院对50名产前和50名产后妇女进行前瞻性观察研究,共100名妇女。缺铁性贫血的诊断应通过适当的病史、检查、外周血涂片和血液指标。随机选择50名产前和产后妇女,在用蔗糖铁或羧麦芽糖铁治疗的第1天、第8天、第15天和第30天记录基线血红蛋白和血清铁蛋白水平。结果:三羧基麦芽糖铁组血红蛋白平均升高4.3 g/L,蔗糖铁组平均升高4.0 g/L。对于产后妇女,用三羧基麦芽糖铁治疗后血红蛋白平均升高4.9 g/L,用蔗糖铁治疗后平均升高4.4 g/L。结论:羧基麦芽糖铁治疗妊娠期及产后缺铁性贫血安全、有效,优于蔗糖铁。
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Comparative Study of Intravenous Iron Sucrose Versus Ferric Carboxymaltose for the Treatment of Iron Deficiency Anemia during Pregnancy and Postpartum Period
Objectives: The present study aims at advantages of ferric carboxymaltose therapy over iron sucrose in iron deficiency anaemia of ante natal and postnatal patient. Methods: A prospective observational study was carried out at ACPM medical college during January 2017 to December 2017 for 50 antenatal and 50 postnatal women, total 100 women. Diagnosis of iron deficiency anemia done by proper history taking, examination, peripheral blood smear and blood indices. Baseline haemoglobin and serum ferritin levels were noted on first, eighth, fifteenth and thirtieth day of treatment with iron sucrose or ferric carboxymaltose for randomly selected 50 antenatal and 50 postnatal women. Results: The mean rise of haemoglobin value was 4.3 g/ L for ferric carboxymaltose and 4.0 g/L for iron sucrose in pregnant women. For postpartum women mean rise of haemoglobin was 4.9 g/L after treatment with ferric carboxymaltose and 4.4 g/L for iron sucrose. Conclusion: For the treatment of iron deficiency anaemia in pregnancy as well as postnatal women ferric carboxymaltose is safe, efficient and having many advantages over iron sucrose.
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