生物医学应用的差分低功率电压箝位ISFET拓扑

Shaghayegh Aslanzadeh, A. Hedayatipour, Mst Shamim Ara Shawkat, N. Mcfarlane
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引用次数: 1

摘要

在过去的几年中,离子敏感场效应晶体管(isfet)在化学检测系统中发挥了重要作用。本文提出了一种适用于生物医学应用的超低功耗CMOS pH传感器架构。该设计采用差分ISFET读出电路,工作在0.9V电源下。通过在亚阈值区域操作mosfet,可以实现最小的电源电压和最小的功耗。该设计的新颖之处在于在差分电压箝位ISFET拓扑中使用不同尺寸的传感栅极区域。ISFET模型是由实验测量得出的。在0.5 μ m标准CMOS工艺下的仿真结果表明,所设计的差分ISFET在1-14pH范围内的平均灵敏度为- 49mV/pH,检测面积为80µm×80µm和10µm×10µm,功率为2.3nW。
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A Differential Low-Power Voltage-Clamped ISFET Topology for Biomedical Applications
Over the past few years, ion-sensitive field-effect transistors (ISFETs) have played a major role in chemical detection systems. This paper presents an architecture for an ultra-low power CMOS pH sensor suitable for biomedical applications. The design uses a differential ISFET readout circuit operating at 0.9V power supply. The minimum supply voltage and minimum power consumption are achieved by operating the MOSFETs in subthreshold regions. The novelty of this design lies in using different size sensing gate areas in a differential voltage clamping ISFET topology. The ISFET model is derived from experimental measurements. Simulation results of the circuit in a 0.5µm standard CMOS process show that the designed differential ISFET provides an average sensitivity −49mV/pH with ISFET sensing areas of 80µm×80µm and 10µm×10µm over a 1-14pH range with 2.3nW of power.
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