Li Ruiyu, Li Yue, L. Xing, L. Meng, Guo Weiya, Zhang Chenyu, L. Qingwen, Hou Jinjie
{"title":"降糖抗聋方对糖尿病性耳聋动物模型血糖的影响","authors":"Li Ruiyu, Li Yue, L. Xing, L. Meng, Guo Weiya, Zhang Chenyu, L. Qingwen, Hou Jinjie","doi":"10.1109/ICCEAI52939.2021.00097","DOIUrl":null,"url":null,"abstract":"Objective: To investigate the effect of lowering sugar and preventing deafness prescription on blood glucose in animal models of diabetic deafness. Methods: Fifty Wistar rats were randomly selected from 40 rats to establish the animal model of experimental diabetic deafness by intraperitoneal injection of 55mg/kg streptozotocin (STZ). The remaining 10 rats were normal control group (group A), and after modeling, they were randomly divided into model control group (group B), low-concentration group (group C) and high-concentration group (group D) of the suspension of the formula for lowering sugar and preventing deafness, metformin control group (group E). Group A was fed the normal diet and given the same dose of normal saline as the other groups, group B was given the same dose of normal saline as the other groups, and the metformin groups in groups C, D and E were given 3.3g/kg.d, 30g/kg.d and 0.3mg/kg.d of hypoglycemic and anti-hearing suspension and metformin aqueous solution, respectively. The administration period was 30 days. Results: Compared with normal control group, fasting blood glucose in model control group was increased, the difference was statistically significant (P < 0.05). Compared with the model control group, the fasting blood glucose level of rats in each group of Jiangtang Fang Deaf Formula was significantly decreased (P < 0.05), and the high dose group of Jiangtang Fang Deaf Formula was superior to the low dose group, but the difference between the two groups was not statistically significant (P > 0.05), and the indexes of each dose group of Jiangtang Fang Deaf Formula were not statistically significant compared with the metformin control group (P BBB>05). Conclusion: Jiangtang Fang Deafness Decoction can improve the blood glucose of diabetic deafness animal models.","PeriodicalId":331409,"journal":{"name":"2021 International Conference on Computer Engineering and Artificial Intelligence (ICCEAI)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of Hypoglycemic Anti-deafness Prescription on Blood Glucose in Animal Model of Diabetic Deafness\",\"authors\":\"Li Ruiyu, Li Yue, L. Xing, L. Meng, Guo Weiya, Zhang Chenyu, L. Qingwen, Hou Jinjie\",\"doi\":\"10.1109/ICCEAI52939.2021.00097\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: To investigate the effect of lowering sugar and preventing deafness prescription on blood glucose in animal models of diabetic deafness. Methods: Fifty Wistar rats were randomly selected from 40 rats to establish the animal model of experimental diabetic deafness by intraperitoneal injection of 55mg/kg streptozotocin (STZ). The remaining 10 rats were normal control group (group A), and after modeling, they were randomly divided into model control group (group B), low-concentration group (group C) and high-concentration group (group D) of the suspension of the formula for lowering sugar and preventing deafness, metformin control group (group E). Group A was fed the normal diet and given the same dose of normal saline as the other groups, group B was given the same dose of normal saline as the other groups, and the metformin groups in groups C, D and E were given 3.3g/kg.d, 30g/kg.d and 0.3mg/kg.d of hypoglycemic and anti-hearing suspension and metformin aqueous solution, respectively. The administration period was 30 days. Results: Compared with normal control group, fasting blood glucose in model control group was increased, the difference was statistically significant (P < 0.05). Compared with the model control group, the fasting blood glucose level of rats in each group of Jiangtang Fang Deaf Formula was significantly decreased (P < 0.05), and the high dose group of Jiangtang Fang Deaf Formula was superior to the low dose group, but the difference between the two groups was not statistically significant (P > 0.05), and the indexes of each dose group of Jiangtang Fang Deaf Formula were not statistically significant compared with the metformin control group (P BBB>05). Conclusion: Jiangtang Fang Deafness Decoction can improve the blood glucose of diabetic deafness animal models.\",\"PeriodicalId\":331409,\"journal\":{\"name\":\"2021 International Conference on Computer Engineering and Artificial Intelligence (ICCEAI)\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2021 International Conference on Computer Engineering and Artificial Intelligence (ICCEAI)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/ICCEAI52939.2021.00097\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2021 International Conference on Computer Engineering and Artificial Intelligence (ICCEAI)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/ICCEAI52939.2021.00097","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effect of Hypoglycemic Anti-deafness Prescription on Blood Glucose in Animal Model of Diabetic Deafness
Objective: To investigate the effect of lowering sugar and preventing deafness prescription on blood glucose in animal models of diabetic deafness. Methods: Fifty Wistar rats were randomly selected from 40 rats to establish the animal model of experimental diabetic deafness by intraperitoneal injection of 55mg/kg streptozotocin (STZ). The remaining 10 rats were normal control group (group A), and after modeling, they were randomly divided into model control group (group B), low-concentration group (group C) and high-concentration group (group D) of the suspension of the formula for lowering sugar and preventing deafness, metformin control group (group E). Group A was fed the normal diet and given the same dose of normal saline as the other groups, group B was given the same dose of normal saline as the other groups, and the metformin groups in groups C, D and E were given 3.3g/kg.d, 30g/kg.d and 0.3mg/kg.d of hypoglycemic and anti-hearing suspension and metformin aqueous solution, respectively. The administration period was 30 days. Results: Compared with normal control group, fasting blood glucose in model control group was increased, the difference was statistically significant (P < 0.05). Compared with the model control group, the fasting blood glucose level of rats in each group of Jiangtang Fang Deaf Formula was significantly decreased (P < 0.05), and the high dose group of Jiangtang Fang Deaf Formula was superior to the low dose group, but the difference between the two groups was not statistically significant (P > 0.05), and the indexes of each dose group of Jiangtang Fang Deaf Formula were not statistically significant compared with the metformin control group (P BBB>05). Conclusion: Jiangtang Fang Deafness Decoction can improve the blood glucose of diabetic deafness animal models.