Immunological Disorders in Adult Patients with Trichophytia and Microsporia of the Genital Area, Tajikistan

To study the state of the main parameters of immunity in the peripheral blood of adult patients with trichophytia and microsporia of the skin of the genitals and surrounding areas. Materials and Methods: 137 patients (88 men, 49 women) aged 16 to 40 years were examined. The duration of the disease was, on average, 6.9 ± 0.2 weeks. 77.4% of patients with mycoses became sexually infected. 28.5% of patients had sexual promiscuity. Research Methods: microscopic, cultural, and immunological. Results: A statistically significant decrease in the number of CD4 lymphocytes (P < 0.02), PANL (P < 0.01), FN (P < 0.01), IL-10 (P < 0.01) and an increase in the content of IgA (P < 0.01), IgM (P < 0.01), CIC (P < 0.01), IL-1β (P < 0.01) and IL-6 (P < 0.01) were detected in the blood of the patients. Patients with a disease duration of up to 1 month showed a change in 8 of the 16 immunological indicators studied, but not a single indicator of cellular immunity, in patients with a disease duration of more than 1 month - 11, including 2 main indicators of cellular immunity (CD3 and CD4 lymphocytes) Conclusion: In adult patients with zoonotic trichophytia and microsporia with atypical localization, there is an inhibition of cellular immunity, phagocytic reactions, anti-inflammatory cytokines and an increase in the activity of humoral and proinflammatory cytokines. Immunological disorders are more pronounced in patients with the disease duration of more than 1 month.