用于迷走神经刺激的微型无线供电和控制植入物

Iman Habibagahi, Jaeeun Jang, A. Babakhani
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引用次数: 2

摘要

多位点刺激在不同的生物医学应用中显示出增强的临床效果。这项工作提出了一种新颖的片上系统(SoC)解决方案,可以使用单个发射器供电和控制多达16个植入式刺激器。植入物可以在40.68MHz工业、科学和医疗(ISM)频段供电,在空气中可达80毫米。每个植入物可以容忍Tx和Rx线圈之间高达70°的错位,并且它们提供了两个恒定电压刺激通道。频率、电压和脉宽使用脉宽调制幅度移位键控(PWM-ASK)无线发送到每个芯片。通过双侧体内(猪)迷走神经刺激(VNS)和体外测量验证了植入装置的性能。植入物直径为14毫米,重量为80毫克。
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Miniaturized Wirelessly Powered and Controlled Implants for Vagus Nerve Stimulation
Multisite stimulation has shown enhanced clinical outcomes in different biomedical applications. This work presents a novel System on Chip (SoC) solution that enables up to 16 implantable stimulators to be powered and controlled using a single transmitter. The implants can be powered at 40.68MHz industrial, scientific and medical (ISM) band up to 80mm in air. Each implant can tolerate up to 70° misalignment between the Tx and Rx coil, and they provide two channels for constant voltage stimulation. The frequency, voltage, and pulse width are sent wirelessly using pulse width modulated amplitude shift keying (PWM-ASK) to each chip. The performance of implantable devices was verified by bilateral in vivo (pig) vagus nerve stimulation (VNS) and in-vitro measurements. The implant has a diameter of 14mm and weighs 80mg.
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