机器学习算法在心脏骤停用药预警系统构建与预测中的应用

Hsiao-ko Chang, Cheng-Tse Wu, Ji-Han Liu, J. Jang
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引用次数: 3

摘要

目的:在本文中,我们着重于使用药物的病人谁有心脏骤停,然后必须做心肺复苏(CPR)。我们想知道药物对预测疾病恶化状态的影响。因此,我们提出了一个心脏骤停药物预警系统(MCAEWS)。它不仅可以帮助医生早期诊断疾病并及时预警,而且可以提高灵敏度,降低假阳性率和死亡率。最重要的作用是大大提高医疗质量。方法:本研究资料来自国立台湾大学附属医院急诊科。从2014年1月到2015年12月。两年内在紧急拘留区停留超过6小时的患者。这些患者被纳入回顾性队列研究。为了比较机器学习模型的度量,我们使用了诸如Receiver Operating Characteristic Curve (AUROC)和Precision-Recall Curve (AUPRC)下的面积。结果:分别对心肺复苏术组和非心肺复苏术组进行数据分析。此外,我们评估了敏感性和特异性。随机森林算法(AUC: 0.98;AUC: 0.94)与Logistic回归算法(AUC: 0.94;AUP: 0.13),决策树(AUC: 0.97;AUP: 0.05),极端随机树(AUC: 0.91;AUP: 0.08),表现为显著的高性能。结论:增加生命体征中的药物因素,可有效提高心脏骤停预测的准确性。本研究结果有助于急诊临床医师和医院质量管理,通过决策支持系统有效解决临床医疗资源配置问题,提高医疗质量。
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Using Machine Learning Algorithms in Medication for Cardiac Arrest Early Warning System Construction and Forecasting
Target-In this paper, we focus on using medicine for patients who have cardiac arrest then must have to do Cardiopulmonary Resuscitation (CPR). We want to know the medicine influence in predicting state of an illness deterioration. Therefore, we proposes a Medication for Cardiac Arrest Early Warning System (MCAEWS). It's not only assist physicians to early diagnose of an illness and immediately warning, but also increase sensitivity, decrease false positive rate and mortality rate. The most important role is greatly improve medical quality. Methods-In this study, the data is from the emergency department of National Taiwan University Hospital (NTUH). It is from January 2014 to December 2015. The patients who stayed in the emergency detention area for more than six hours during this two years. The patients were included in the retrospective cohort study. To comparative measures for the machine learning models, we used such as the Area Under the Receiver Operating Characteristic Curve (AUROC) and the Area under the Precision-Recall Curve (AUPRC). Results-The data were analyzed for CPR and non-CPR groups respectively. Furthermore, we evaluated sensitivity and specificity. The Random Forest Algorithm (AUC: 0.98; AUP: 0.23) compare with others such as Logistic Regression Algorithm (AUC: 0.94; AUP: 0.13), Decision Tree (AUC: 0.97; AUP: 0.05), and Extreme Random Tree (AUC: 0.91; AUP: 0.08), it was significantly high performance. Conclusion-Increasing the drug factors in vital signs, that it effectively improved the accuracy of predicting cardiac arrest. The results of this study, it's help for emergency clinical Physicians and hospital quality management will validly solve clinical medical resource allocation issues and improve medical quality through decision support systems.
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