多结合生物素化氧化铁纳米颗粒(生物素- ionps)作为磁性生物检测设备有前途的多功能标记材料的研究

Yimeng Du, P. Pong
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摘要

通过实现磁性标记与每个生物分子的多重结合,可以提高磁性生物检测装置的灵敏度。本研究合成了生物素化氧化铁纳米颗粒(生物素- ionps),并研究了其与链霉亲和素功能化生物分子的多重结合。最终获得的磁芯尺寸为17 nm的生物素- ionps在金表面和溶液中均表现出超顺磁性、亲水性稳定性以及与链霉亲和素功能化抗体的多重结合能力。因此,生物素离子是一种很有前途的磁性标记材料,可用于改进磁性生物检测设备。
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Study of the multi-binding biotinylated Iron oxide nanoparticles (biotin-IONPs) as a promising versatile label material for magnetic biodetection devices
By realizing the multi-binding of magnetic labels with each biomolecule, the sensitivity of magnetic biodetection devices can be improved. In this study, biotinylated iron oxide nanoparticles (biotin-IONPs) were synthesized, and their multi-binding with streptavidin-functionalized biomolecules was investigated. The final biotin-IONPs with 17 nm magnetic core size exhibit superparamagnetic behavior, hydrophilic stability, and multi-binding ability with streptavidin-functionalized antibodies both on gold surfaces and suspended in solution. Consequently, biotin-IONPs are promising magnetic label materials for the improvement of magnetic biodetection devices.
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