抗利尿激素抢救治疗在新生儿持续性肺动脉高压中的应用

Section on Neonatal-Perinatal Medicine Program Pub Date : 2021-02-24 DOI:10.1542/PEDS.147.3_MEETINGABSTRACT.749

S. Joshi, Vilmaris Quiñones Cardona, Ogechukwu R. Menkiti

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摘要

背景:新生儿持续性肺动脉高压(PPHN)影响1.9 / 1000活产，死亡率在4-33%之间。虽然吸入一氧化氮(iNO)减少了这一人群对体外膜氧合(ECMO)的需求，但难治性病例仍然存在。加压素作为一种治疗新生儿的方法越来越受欢迎，尽管数据有限，并且对低钠血症和肠道灌注减少有担忧。目的:探讨加压素对大鼠氧合及全身血液循环的影响。

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Utility of Vasopressin Rescue Therapy in Neonates with Persistent Pulmonary Hypertension of the Newborn

Background: Persistent pulmonary hypertension of newborn (PPHN) affects 1.9 per 1000 live births and has a varied mortality ranging between 4-33%. Although inhaled nitric oxide (iNO) has reduced the need for Extracorporeal membrane oxygenation (ECMO) in this population, refractory cases persist. Vasopressin is gaining favor as a treatment modality in neonates despite limited data and concerns for hyponatremia and decreased intestinal perfusion. Objective: To describe the effect of vasopressin on oxygenation and systemic blood …

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Section on Neonatal-Perinatal Medicine Program

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