Obezitenin Genotoksik Etkileri

Obesity is considered as a disease, which affects the whole world. Recent years, epidemiological studies linking obesity with increased risk of cancer is steadily increasing. Studies suggest that obesity might be a risk for genotoxic damage. Obesity-associated genotoxic damage can initiator, promote cancer growth by favoring cancer cell proliferation and migration, and blocking to apoptosis. Obesity can change the repair mechanism of DNA chain breaks. In addition, the increase in oxidative stress and inflammation associated with obesity could increase DNA damage and prevent DNA functioning mechanisms, resulting in DNA damage transformation into a cancerous cell. Studies over the past few years have shown that obesity can affect genome stability. In this review article, the genotoxic effects of obesity are explained in detail.